The Feasibility of a Radiological Score Based on CT Signs for Recognizing Salvageable Bowel in Acute Mesenteric Ischemia

Recruiting

• Conditions: Acute Mesenteric Ischemia

• Registration Number: NCT06445660
• Lead Sponsor: University of Tartu

Brief Summary

Computed tomography (CT) is the standard modality for scanning patients with critical acute abdominal conditions, including suspected acute mesenteric ischemia (AMI). CT imaging can potentially differentiate between reversible and irreversible ischaemic damage of the bowel. This moment is pivotal in selecting the treatment strategy for AMI - in the absence of irreversible damage; reperfusion therapy can preserve intestinal viability, thereby avoiding the need for bowel resection. The present study tests the hypothesis that combining several symptoms may enhance the diagnostic performance of CT scanning in detecting salvageable bowel in patients with AMI. This study is an ancillary component of the AMESI study (Clinical Trials: NCT05218863) - a prospective, multicentre observational study aimed at identifying the incidence and describing the outcomes of acute mesenteric ischemia (AMI) in adult hospitalized patients. The ultimate purpose of the present study is to create a computed tomography-based radiological score for the assessment of bowel viability in patients with AMI.

Detailed Description

Not available

Study Timeline

• Study Start: 2022-06-06
• Primary Completion: 2023-04-05
• Study First Submitted: 2024-05-22
• Study First Submitted QC: 2024-05-31
• Study First Posted: 2024-06-06
• Status Verified: 2025-03
• Last Update Submitted: 2025-03-24
• Last Update Posted: 2025-03-25
• Study Completion: 2025-05-31

Recruitment & Eligibility

• Status: RECRUITING
• Sex: All
• Target Recruitment: 200

Inclusion Criteria

• Participant in AMESI study
• confirmed or suspected acute mesenteric ischaemia
• CT scan of the entire abdominal cavity / full body using intravenous contrast media is available

Exclusion Criteria

• Scans without the use of an intravenous contrast media or those covering only a partial area of the abdomen will be excluded.

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Frequency rate	up to one month	Frequency rate of common radiological signs in AMI patients with and without salvageable bowel.

Secondary Outcome Measures

Name	Time	Method
Performance of the radiological score	up to one month	Performance of the radiological score in patients with different types of AMI.

Trial Locations

Locations (1)

Tartu University Hospital; 🇪🇪 Tartu, Estonia