Pressure Pain Tolerance in Relation to Balance and Strength in Children
- Conditions
- Sickle Cell Anemia
- Interventions
- Other: Pressure pain tolerance measurement using Digital Pressure AlgometerOther: Balance assessment using HUMAC balance systemOther: Lower limb muscular strength using Lafayette hand held dynamometer
- Registration Number
- NCT06529874
- Lead Sponsor
- Adly A Adam
- Brief Summary
Sickle cell disease (SCD) is the most frequent life-threatening genetic hemoglobinopathy in the world and occurs due to the synthesis of abnormal hemoglobin S (HbS).Cells with sickle cell hemoglobin are stiff and sticky. When they lose their oxygen, they form into the shape of a sickle or crescent. This can cause pain and tissue damage. Significant decrease in exercise capacity was seen in sickle cell anemic children. In the absence of a guidelines that can guide the prescription of exercise in SCD children. This study is a step for determine the forms of prescription of pain on the balance and muscle strength to build up in future studies a safety of physical exercises for children with sickle cell anemia and improve their functional abilities.
- Detailed Description
Sickle cell anemia is a serious life-limiting and potentially life-threatening condition that causes disruption in the lifestyle of the affected child. Pain is a common and severe symptom of sickle cell disease (SCD) and is the major reason that patients seek health care services. Some researchers supported the fact that an important impairment in balance control and muscle strength in children with sickle cell disease due to pressure pain tolerance problems and other factors. Significant decrease in exercise capacity was seen in sickle cell anemic children. The altered muscle function and balance observed in SCD children may collectively be the result of pressure pain tolerance impairment. As your physical fitness improves, your body becomes more efficient at getting oxygen into the bloodstream and transporting it to the working muscles. Along this observational correlational study design; Eighty children from both sexes will be participated in this study. Forty normal healthy children will be selected from primary governmental schools at Alexandria governorate and forty children with sickle cell anemia will be selected from Alexandria University Students Hospitals For evaluation of muscle strength hand held dynamometer (Lafayette) is one of the best methods to detect the muscle strength. It is an ergonomic hand-held device for objectively quantifying muscle strength
Recruitment & Eligibility
- Status
- RECRUITING
- Sex
- All
- Target Recruitment
- 80
- Age range range was 9-14 years old.
- Could follow given instructions.
- Children with Sickle cell anemia were medically stable, and take their medications regularly.
- Children with Sickle cell anemia had experience of chronic pain that lasts more than 6 months.
- All children with Sickle cell anemia have average weight, height, and body mass index based on their age percentiles.
- All normal healthy children did not participating in regular sport activities, particularly including lower limb strengthening.
- Defined cardiovascular or respiratory disorders.
- Renal failure.
- Myocardial infarction, mainly within last month.
- Unstable angina.
- Recent thoracoabdominal surgery.
- Thoracic or abdominal aneurysm or current pneumothorax.
- Painful vaso-occlusive crises.
- Muscular contractures, Joints' stiffness, or deformities.
- Neuromuscular problems i.e., myositis or peripheral neuropathy.
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description Normal Healthy children Pressure pain tolerance measurement using Digital Pressure Algometer All forty normal healthy children will undergo measurement of pressure pain tolerance via digital pressure algometry, balance assessment using HUMAC balance system, and evaluation lower limb strength using Lafayette Hand Held Dynamometer. Normal Healthy children Lower limb muscular strength using Lafayette hand held dynamometer All forty normal healthy children will undergo measurement of pressure pain tolerance via digital pressure algometry, balance assessment using HUMAC balance system, and evaluation lower limb strength using Lafayette Hand Held Dynamometer. Sickle cell anemia children Pressure pain tolerance measurement using Digital Pressure Algometer All forty Sickle cell anemia children will undergo measurement of pressure pain tolerance via digital pressure algometry, balance assessment using HUMAC balance system, and evaluation lower limb strength using Lafayette Hand Held Dynamometer. Sickle cell anemia children Lower limb muscular strength using Lafayette hand held dynamometer All forty Sickle cell anemia children will undergo measurement of pressure pain tolerance via digital pressure algometry, balance assessment using HUMAC balance system, and evaluation lower limb strength using Lafayette Hand Held Dynamometer. Normal Healthy children Balance assessment using HUMAC balance system All forty normal healthy children will undergo measurement of pressure pain tolerance via digital pressure algometry, balance assessment using HUMAC balance system, and evaluation lower limb strength using Lafayette Hand Held Dynamometer. Sickle cell anemia children Balance assessment using HUMAC balance system All forty Sickle cell anemia children will undergo measurement of pressure pain tolerance via digital pressure algometry, balance assessment using HUMAC balance system, and evaluation lower limb strength using Lafayette Hand Held Dynamometer.
- Primary Outcome Measures
Name Time Method Pressure pain tolerance Baseline of the study. Pressure pain tolerance measured via digital pressure algometer. It determines the pressure amount could be tolerated over quadriceps. This will represented chronic pain among Sickle cell anemia children in order to aid in diagnosis of hyperalgesia thus provide insight into their management strategies. Digital pressure algometer determines enables the rater to quantify the mechanical sensitivity to pain and the recovery of underlying problems or soreness levels in a semi-objective manner.
Balance assessment Baseline of the study. Balance assessed via HUMAC balance system to define musculoskeletal involvement in sickle cell anemia children. HUMAC balance system is an electronic balance board connected with laptop running HUMAC balance system software.
Lower limb muscle strength Baseline of the study. Lower limb muscle (Quadriceps) strength evaluated via Lafayette hand held dynamometer to evaluate voluntary isometric contraction. Hand held dynamometer has a good to excellent reliability and validity mainly for proximal musculatures.
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
El-Tahrir st.- in front of Ben El-Sarayat, Ad Doqi Al Giza, Giza Governate
🇪🇬Giza, Egypt