Neurovascular Complications and White Matter Damage in Acquired Anemias
试验速览
- 阶段
- 不适用
- 状态
- 撤回
- 试验地点
- 4
- 主要终点
- Impact of acquired anemia on cerebrovascular oxygen delivery (ml O2/100g/min)
研究概览
简要总结
This is an observational trial, in patients with moderate to severe anemia and control subjects. The main purpose of this study is to understand whether normal brain blood flow, oxygen extraction reserve, white matter volumes, and brain functional connectivity are affected by acquired anemia. The investigators will perform baseline MRI monitoring for all subjects. All eligible subjects will be asked to provide informed consent before participating in the study.
详细描述
This is an observational trial, in patients with moderate to severe anemia and control subjects. The main purpose of this study is to understand whether normal brain blood flow, oxygen extraction reserve, white matter volumes, and brain functional connectivity are affected by acquired anemia. The investigators will perform baseline MRI monitoring for all subjects. All eligible subjects will be asked to provide informed consent before participating in the study. Comprehensive cerebrovascular MRI, baseline bloodwork, and neurocognitive testing will be collected from all subjects.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 16 Years 至 60 Years（Child, Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- 未提供
排除标准
- 未提供
结局指标
主要结局
Impact of acquired anemia on cerebrovascular oxygen delivery (ml O2/100g/min)
时间窗: Day 0
Impact of acquired anemia on cerebrovascular oxygen delivery will be assessed by measuring cerebral blood flow and oxygen content through MRI.
Impact of acquired anemia on cerebrovascular flow reactivity (%SI change/%ETCO2)
时间窗: Day 0
baseline MRI with blood oxygenation level dependent (BOLD) acquisition will be assessed in response to carbon dioxide exposure to determine whether acquired anemia affects cerebrovascular reserve
Impact of acquired anemia on total brain blood flow (ml blood/100g/min)
时间窗: Day 0
Phase contrast MRI will be assessed to determine whether acquired anemia affects total brain blood flow
Impact of acquired anemia on blood brain barrier permeability surface area product (ml H20/100g/min)
时间窗: Day 0
baseline PSA product using water-extraction-with-phase-contrast-arterial-spin-tagging (WEPCAST) MRI will be assessed to determine whether acquired anemia affects blood brain barrier permeability to water
Impact of acquired anemia on cerebral metabolic rate of oxygen (ml O2/100g/min)
时间窗: Day 0
T2 relaxation under spin tagging (TRUST) acquisition via MRI will be used to assess any impact of anemia on cerebral metabolic rate of oxygen.
次要结局
未报告次要终点
研究者
John C. Wood
Professor
Children's Hospital Los Angeles