The Impact of Intraoperative Carbon Dioxide Wound Ventilation on Cerebral Microembolic Load during Aortic Arch Surgery : a Prospective Randomized Clinical Trial using Transcranial Doppler Ultrasound

Phase 3

• Conditions: (minor; cognitive function; major or silent stroke); 10014523; paralysis; 10003184; postoperative stroke; 10007963

• Registration Number: NL-OMON30090
• Lead Sponsor: St. Antonius Ziekenhuis

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 18 June 2024

Recruitment & Eligibility

• Status: Pending
• Sex: Not specified
• Target Recruitment: 30

Inclusion Criteria

all patients accepted for elective surgery on the ascending aorta and aortic arch via median sternotomy

Exclusion Criteria

- emergency operation (including type A dissection)
- patients with a difficult transtemporal acoustic ultrasound *bone window*
- patients with claustrophobia and therefore unwilling to have magnetic resonance brain imaging or that have other contra-indications for this investigation (pacemakers, etc.)
- patients with a more than 60% stenosis or occlusion of one or both carotid arteries
- intraoperative technical failure of TCD registration

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>Number of cerebral microemboli counted on Transcranial Doppler ultrasound<br /><br>recordings</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>Postoperative ischemic reactions in the brain assessed by diffusion-weighted<br /><br>magnetic resonance imaging of the brain</p><br>