The effect of changing CO2 levels on perioperative cerebral and microcirculatory hemodynamics in infants undergoing laparoscopic surgery

• Conditions: Diseases that require surgical correction through laparoscopic surgery; 10018018

• Registration Number: NL-OMON48061
• Lead Sponsor: Erasmus MC, Universitair Medisch Centrum Rotterdam

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 15 April 2024

Recruitment & Eligibility

• Status: Pending
• Sex: Not specified
• Target Recruitment: 15

Inclusion Criteria

Cardiovascular healthy children 0 to 1 year of age undergoing laparoscopic
surgery

Exclusion Criteria

- Absence or refusal of parental informed consent;
- Preterm new born (adjusted age * 36 weeks);
- Cardiovascular, pulmonary, renal, oncological disease;
- Genetic syndrome

Study & Design

• Study Type: Observational non invasive
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>- End tidal CO2 (etCO2, kPa);<br /><br>- Transcutaneous partial pressure CO2 (PCCO2, kPa);<br /><br>- Sublingual microcirculation: parameters of vessel density (total vessel<br /><br>density (TVD, mm/mm2) and perfused vessel density (PVD, mm/mm2)) and parameters<br /><br>of vascular perfusion (microvascular flow index (MFI), proportion of perfused<br /><br>vessels (PPV, %), red blood cell velocities (RBCV, mm/s) and heterogeneity<br /><br>index of flow (heterogeneity index (HI)));<br /><br>- Cerebral oxygenation: regional cerebral oxygen saturation (rScO2, %);<br /><br>- Cerebral perfusion: cerebral blood flow velocities (CBFV, cm/s) of the<br /><br>lateral striate artery and the medial cerebral artery;<br /><br>- Cerebral activity: neuronal electrical activity and background patterns over<br /><br>time. </p><br>

Secondary Outcome Measures

Name	Time	Method
<p>Not applicable</p><br>