Age and Sleep Apnea Syndrome

• Conditions: OSA; Age Problem
• Interventions: Other: Age; Other: OSA

• Registration Number: NCT03885440
• Lead Sponsor: Taipei Veterans General Hospital, Taiwan

Brief Summary

By clinical record review, this retrospective study aims to compare the different age groups of patients with obstructive sleep apnea, who were diagnosed and treated in Taipei Veterans General Hospital, Taiwan.

Detailed Description

This retrospective study aims to compare the characteristics of patients with obstructive sleep apnea (OSA). Patients with sleep problem and received a prior polysomnography at Taipei Veterans General Hospital during Jan. 1, 2016 to Dec. 31, 2017 will be enrolled. Obstructive sleep apnea (OSA) is defined by an apnea-hypopnea index(AHI) at least 5/hr with compatible symptoms. Their clinical record will be reviewed and data including demography, polysomnography, comorbidities and details related to upper airway structure will be collected. The charactereistics would be compared with Student's t tests, Mann-Whitney U tests, or Chi square tests if appropriated.

Study Timeline

• Study First Submitted: 2019-03-16
• Study First Submitted QC: 2019-03-19
• Study First Posted: 2019-03-21
• Status Verified: 2019-04
• Study Start: 2019-04-08
• Last Update Submitted: 2019-04-08
• Last Update Posted: 2019-04-09
• Primary Completion: 2019-06-30
• Study Completion: 2019-09-30

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 3000

Inclusion Criteria

• Patients with sleep complaints and received PSG in sleep center in Taipei Veterans General Hospital

Exclusion Criteria

• Patients who ever received treatment for OSA
• Patients cannot tolerate PSG examination
• Patients cannot complete the questionnaires before and after PSG examination

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
Young adult, with OSAS	OSA	20\<=Age\<40 years old, AHI\>=5
Young adult, with OSAS	Age	20\<=Age\<40 years old, AHI\>=5
Young adult, without OSAS	Age	20\<=Age\<40 years old, apnea-hypopnea index(AHI)\<5
older adult, with OSAS	OSA	Age\>=40 years old, AHI\>=5

Primary Outcome Measures

Name	Time	Method
Apnea-hypopnea index(AHI)	through study completion, an average of 1 year	Counts of apnea/hypopnea events per hour

Secondary Outcome Measures

Name	Time	Method
Body mass index(BMI)	through study completion, an average of 1 year	The body mass divided by the square of the body height.
Posterior airway space (PAS)	through study completion, an average of 1 year	The diameter from supramentale to gonion.
Number of participants with comorbidities	through study completion, an average of 1 year	Self-reported comorbidities including cardiovascular disease, stroke, hypertension, diabetes mellitus, hyperlipidemia, lung disease, anxiety, depression.
arousal index	through study completion, an average of 1 year	The number of arousals and awakenings as a frequency per hour of sleep.
Sleep efficiency	through study completion, an average of 1 year	The ratio of the total time spent asleep (total sleep time) in a night compared to the total amount of time spent in bed.
oxygen desaturation index	through study completion, an average of 1 year	The number of times per hour of sleep that the blood's oxygen level drop by 4% from baseline.

Trial Locations

Locations (1)

Chest department, Taipei Veteran General Hospital; 🇨🇳 Taipei City, Taiwan