Changes in Adrenal Hormones During Adrenal Radiofrequency Ablation
试验速览
- 阶段
- 2 期
- 状态
- 已完成
- 入组人数
- 18
- 试验地点
- 4
- 主要终点
- Increase in Catecholamine
研究概览
简要总结
The purpose of this study is to evaluate changes in adrenal hormones during adrenal radiofrequency (RF) ablation.
详细描述
Adrenal radiofrequency (RF) ablation has been increasingly used for the treatment of unresectable adrenal tumors. But one of the major complication is a increase in blood pressure. Hormonal release during RF ablation is considered the cause of hypertension. But there has been no evidence that adrenal hormones affects changes in blood pressure. In this prospective study, we evaluate the changes in adrenal hormones during RF ablation and clarify the cause of hypertensive crisis.
研究设计
- 研究类型
- Interventional
- 分配方式
- Non Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 20 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Unresectable adrenal tumor which will be treated by radiofrequency (RF)ablation
- •Blood pressure is 140mmHg or less before RF ablation
- •Age of 20-years or more
- •Performance status of 0 or 1
- •Agreement from the patient
排除标准
- •Platelet count of 50,000/mm^3 or International normalized ratio (INR)>1.5
结局指标
主要结局
Increase in Catecholamine
时间窗: One day
Serum Cathecholamine Levels
时间窗: around one year
Number of Participants With Hypertension During Adrenal or Non-adrenal Radiofrequency Ablation
时间窗: 1 week
Blood pressure was monitored during radiofrequency (RF) ablation. The frequency of hypertension (systolic blood pressure of more than 200 mmHg) was evaluated and compared between the adrenal and non-adrenal (RF ablation other than adrenal gland) RF ablation groups.
次要结局
- Increase in Cortisol(1 day)
研究者
Koichiro Yamakado
Clinical Professor
Mie University