Laparoscopic Adrenalectomy Versus Radiofrequency Ablation
Not Applicable
- Conditions
- HyperaldosteronismConn SyndromeAdrenocortical Adenoma
- Registration Number
- NCT02030587
- Lead Sponsor
- Chinese University of Hong Kong
- Brief Summary
This is a prospective randomized controlled study comparing laparoscopic adrenalectomy (LA) versus image-guided percutaneous radiofrequency ablation (RFA) in treating aldosterone-producing adenoma.
The objectives of this study are to
1. compare the short-term outcomes of LA and RFA in treating aldosterone-producing adenoma.
2. compare the treatment success rates of LA and RFA during follow-up for primary aldosteronism.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- UNKNOWN
- Sex
- All
- Target Recruitment
- 36
Inclusion Criteria
- Hypertensive individuals
- Biochemically confirmed primary aldosteronism
- Radiologically confirmed unilateral adrenal adenoma ≤3cm
Exclusion Criteria
- Bilateral adrenal disease
- Multiple adrenal tumors
- Other concomitant adrenal diseases
- Potentially malignant adrenal tumors as shown on imaging
- Uncorrected coagulopathy
- Surgically unfit for general anaesthesia
- Prior open abdominal surgery
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- CROSSOVER
- Primary Outcome Measures
Name Time Method Morbidity rate 30-day Resolution of hyperaldosteronism 1 year
- Secondary Outcome Measures
Name Time Method Time to resumption of activity 30 days Analgesic requirement 30 days Operative time 24 hours Periprocedural hypertensive crisis 24 hours Hospital stay 30 days Mortality rate 30 days Blood loss 24 hours Resolution of hypokalaemia 1 year Blood pressure control 1 year Pain score 7 days
Related Research Topics
Explore scientific publications, clinical data analysis, treatment approaches, and expert-compiled information related to the mechanisms and outcomes of this trial. Click any topic for comprehensive research insights.
What are the molecular mechanisms underlying aldosterone overproduction in Conn Syndrome and how do they influence treatment selection between LA and RFA?
How does laparoscopic adrenalectomy compare to radiofrequency ablation in managing primary aldosteronism versus other adrenocortical adenoma treatments?
Which biomarkers are most predictive of long-term treatment success in patients undergoing RFA versus LA for aldosterone-producing adenomas?
What are the potential adverse events associated with image-guided percutaneous RFA for hyperaldosteronism and how do they compare to LA complications?
Are there emerging targeted therapies or combination approaches for Conn Syndrome that could complement or challenge LA and RFA interventions?
Trial Locations
- Locations (1)
Prince of Wales Hospital
🇭🇰Shatin, Hong Kong
Prince of Wales Hospital🇭🇰Shatin, Hong Kong