Effect of Sacubitril/ Valsartan and ramipril on coronary bypass surgery patient.
Not Applicable
- Conditions
- Health Condition 1: - Health Condition 2: I257- Atherosclerosis of coronary arterybypass graft(s) and coronary artery of transplanted heart with angina pectoris
- Registration Number
- CTRI/2020/02/023488
- Lead Sponsor
- Soumitra Mandal
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- ot Yet Recruiting
- Sex
- Not specified
- Target Recruitment
- 0
Inclusion Criteria
I.Patients planning for CABG
II.Age in between 30 to 70 years.
III.New York Heart association (NYHA) functional class II-IV symptoms for heart failure.
IV.Ejection fraction of 40% or less.
Exclusion Criteria
I.Symptomatic hypotension (Systolic blood pressure < 100 mm hg).
II.Estimated glomerular filtration rate <30 ml/min/1.73 m2 [Gfr estimated by MDRD study equation]
III.Hypersensitivity to study medication.
IV.Any history of angioedema.
V.Concomitant use with any drug formulation containing an angiotensin-converting enzyme inhibitor.
Study & Design
- Study Type
- Observational
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method 1.The change in ejection fraction in the both group compare to baseline at 30 days and 90 days. <br/ ><br>2.Change in left ventricular end systolic diameter, left ventricular end-diastolic diameter, LV mass (reverse remodeling parameters) in the both group compare to baseline at 30 days and 90 days. <br/ ><br>Timepoint: Both group compare to baseline at 30 days and 90 days post operative days. <br/ ><br>
- Secondary Outcome Measures
Name Time Method 1.Proportion of patients died due to cardiovascular cause in each group. <br/ ><br>2.Proportion of patientsâ?? hospitalization due to cardiovascular cause in each group. <br/ ><br>3.Proportion of patients died due to noncardiovascular cause in each group. <br/ ><br>4.Proportion of patientsâ?? hospitalization due to noncardiovascular cause in each group. <br/ ><br>Timepoint: Both group compare to baseline at 30 days and 90 days post operative days.