The Impact of Heat Acclimation on Pro- and Anti- Inflammatory Cytokine Response
Trial Snapshot
- Phase
- Not Applicable
- Status
- Terminated
- Sponsor
- Enrollment
- 10
- Locations
- 2
- Primary Endpoint
- Investigating the variability in the levels of different cytokine and the kinetics in cytokine levels during the process of acclimation to heat.
Study Overview
Brief Summary
There is growing evidence to conclude that part of the cascade leading to heatstroke is related to an inflammatory reaction triggered by the heat stress. The reduced ability to sustain heat stress - "heat intolerance" is also attributed to over-expression of inflammatory cytokines. Acclimation to heat improves human sustainability to heat and is a leading protective factor against heat stroke. The investigators hypothesize that the lower stress encountered during the process of acclimation to heat will be reflected by an over-ride in the expression of anti-inflammatory over the pro-inflammatory cytokines. This, in turn will attenuate the pathological cascade leading to heat stroke.
Study Design
- Study Type
- Interventional
- Allocation
- Na
- Intervention Model
- Single Group
- Primary Purpose
- Basic Science
- Masking
- Single (Investigator)
Eligibility Criteria
- Ages
- 18 Years to 25 Years (Adult)
- Sex
- Male
- Accepts Healthy Volunteers
- Yes
Inclusion Criteria
- •age:18-25
- •medically screened (healthy)
Exclusion Criteria
- •BMI over 22 kg/m2
- •systolic blood pressure over 120 mmHg
- •any febrile illness during the last week preceding the study
- •any skin disease
- •any heart conditions.
Outcomes
Primary Outcomes
Investigating the variability in the levels of different cytokine and the kinetics in cytokine levels during the process of acclimation to heat.
Time Frame: 12 days
Secondary Outcomes
No secondary outcomes reported
Investigators
Prof. Yoram Epstein
Heller institue, Sheba Medical Center
Sheba Medical Center