Effects of Transcranial Direct Current Stimulation (tDCS) on GABA Concentration and Brain Functional Connectivity in Young Adults.

Charite University, Berlin, Germany1 site in 1 country32 target enrollmentApril 2016

ConditionsHealthy Young Adults

Overview

Phase: Not Applicable
Intervention: Not specified
Conditions: Healthy Young Adults
Sponsor: Charite University, Berlin, Germany
Enrollment: 32
Locations: 1
Primary Endpoint: Measurement of GABA concentration by magnetic resonance spectroscopy (MRS) after anodal tDCS adjusted for baseline levels.
Status: Completed
Last Updated: 9 years ago

Overview Investigators Eligibility Criteria Outcomes Sites Similar Trials

Overview

Brief Summary

The aim of this study is to investigate whether anodal tDCS over the left M1 leads to a decrease of GABA concentration and alterations of functional brain connectivity in younger people, compared to sham tDCS.

Registry

clinicaltrials.gov

Start Date

April 2016

End Date

December 2016

Last Updated

9 years ago

Study Type

Interventional

Study Design

Crossover

Sex

All

Investigators

Sponsor

Charite University, Berlin, Germany

Responsible Party

Principal Investigator

Agnes Flöel

Prof. Dr.

Charite University, Berlin, Germany

Eligibility Criteria

Inclusion Criteria

•unobtrusive neuropsychological screening
•age: young adults: 18-30 years

Exclusion Criteria

•Mild cognitive impairment (MCI) or other neurological diseases
•History of severe alcoholism or use of drugs
•Severe psychiatric disorders such as depression, psychosis (if not in remission) and severe untreated medical problems
•Contraindication for MRI (claustrophobia, metallic implants, ferromagnetic metals in the body, disorders of thermoregulation, pregnant women)

Outcomes

Primary Outcomes

Measurement of GABA concentration by magnetic resonance spectroscopy (MRS) after anodal tDCS adjusted for baseline levels.

Time Frame: assessed immediately before and after a 15-min stimulation time

Investigation whether anodal tDCS leads to a significant reduction of M1-GABA concentration in younger adults compared to sham stimulation.

Secondary Outcomes

Genotyping of learning related polymorphisms.(assessed during baseline screening)
GABA concentration assessed by MRS after cathodal tDCS adjusted for baseline levels(assessed immediately before and after a 15-min stimulation time)
Resting-state functional connectivity changes(assessed during a 15-min stimulation time)