Study on acupuncture and moxibustion improving endometrial receptivity of patients with endometrial atypical hyperplasia and endometrial cancer after fertility preserving therapy (2) A prospective study of endometrial hyperplasia
- Conditions
- Endometrial Cancer and Endometrial Atypical Hyperplasia
- Registration Number
- ITMCTR2100004812
- Lead Sponsor
- Obstetrics and Gynecology Department, Peking University People's Hospital
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- Female
- Target Recruitment
- Not specified
(1) Aged <= 40 years, have strong desire to have children;
(2) atypical hyperplasia of uterus, endometrial cancer progesterone treatment remission;
(3) endometrial cancer iag1-iag2 stage, endometrial atypical hyperplasia;
(4) imaging examination confirmed that the tumor was confined to the endometrium;
(5) estrogen and progesterone receptor (ER, PR) were positive;
(6) peripheral blood CA125;
(7) no contraindication of progesterone treatment;
(8) evaluation of reproductive function before treatment, no other factors of fertility disorders;
(9) after complete remission, when the dominant follicle in follicular phase reached 15 mm, the endometrial thickness was less than 7.0 mm;
(10) acupuncture treatment was used to improve the endometrial receptivity after preserving reproductive function;
(11) informed consent was signed, and good follow-up conditions were available.
(1) Patients with severe medical diseases and severe impairment of liver and kidney function;
(2) patients with endometrioid adenocarcinoma whose pathological stage or grade is higher than stage IA G1, or with deep myometrial invasion, cervical invasion or distant metastasis in pelvic and abdominal cavity;
(3) patients with drug allergy and contraindications;
(4) patients with other types of endometrial cancer or other malignant tumors of reproductive system; patients with breast cancer or other malignant tumors He can not use progesterone hormone dependent tumor;
(5) require hysterectomy or other methods of treatment except conservative treatment;
(6) deep vein thrombosis, stroke, myocardial infarction;
(7) allergic constitution or allergic to acupuncture.
Study & Design
- Study Type
- Observational study
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Endometrial thickness;
- Secondary Outcome Measures
Name Time Method Pittsburgh sleep quality index;Endometrial morphology;Anxiety and depression assessment;Early spontaneous abortion rate;Live birth rate;Preterm birth rate;Available embryo rate;Recurrence rate;High quality embryo rate;Incidence rate of complications during pregnancy;Endometrial peristalsis;Clinical pregnancy rate;Egg rate;Embryo implantation rate;Endometrial blood flow;Relapse free survival;