To study whether Remdesivir (an antiviral, used for the treatment of COVID - 19) is effective in COVID 19 patients with respect to complications of the disease or death.

Not yet recruiting

Brief Summary: The emergence of COVID 19 virus as a global pandemic has posed a serious health threat worldwide. This novel corona virus has no specific treatment and various drugs with other indications have been tried. Remdesivir, an antiviral has showed some invitro activity against SARS-CoV-2. The clinical effectiveness of this drug is yet to be proven, with varied results from different clinical trials. Hence, this study is being undertaken to look for the impact of Remdesivir in COVID 19 patients.

All patients who were admitted in KH during the specified period with moderate and severe COVID will be included in the study. Demographics of patients, their COVID status (moderate or severe), their comorbidities and details of hospital stay, including stay in ICU, need for oxygen, need for mechanical ventilation will be documented.

Details of the therapy they received for COVID -19, including remdesivir and day of administration ,along with other drugs given , and supportive care will be noted.

The number of days of hospital stay and ICU stay and the outcomes in the form of survival or death will be collected.

These details will be statistically analyzed

Recruitment & Eligibility

Inclusion Criteria

All patient admitted in Kasturba Hospital, Manipal with COVID-19 positive by RTPCR / RAT between April 2020 and October 2020 2.
All patient categorized as moderate or severe COVID as per standard guidelines.

Exclusion Criteria

Patients who have sepsis from other sources 2.
Patients with underlying lung disease like COPD, ILD, destroyed lung which may contribute to their hypoxia .
Patients with malignancy and other causes of immune suppression.
Patients who are pregnant.

Primary Outcome Measures

Name	Time	Method
The impact of remdesivir on outcomes in these patients will be analyzed	On admission, during the hospital stay till discharge of the patient

Secondary Outcome Measures

Name	Time	Method
Comorbidities	Details of hospital stay

Locations (1): Kasturba Medical College and Kasturba Hospital Manipal
🇮🇳
Udupi, KARNATAKA, India
Kasturba Medical College and Kasturba Hospital Manipal
🇮🇳Udupi, KARNATAKA, India
Dr Sneha S
Principal investigator
9741970110
sneha.s@manipal.edu