A prospective, double-blinded, randomized controlled trial to evaluate the efficacy of intravenous nefopam on postoperative opioid consumption after laparoscopic liver surgery
- Conditions
- Patients after laparoscopic liver surgeryNefopam, Laparoscopic liver surgery, Postoperative pain, Opioid consumption
- Registration Number
- TCTR20230428001
- Lead Sponsor
- Khon Kaen University
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Active, not recruiting
- Sex
- All
- Target Recruitment
- 104
1. Age 18-65 years old
2. Patient who undergoing laparoscopic liver surgery
3. ASA classification I-III
1. Severe systemic medical condition such as poor-controlled hypertension, heart disease, lung disease, renal dysfunction with GFR less than 60, poor-controlled diabetes mellitus, Child-Pugh class B or C, Abnormal liver function test (total bilirubin > 2 mg/dL, INR > 1.7, albumin < 3,5 g/dL, or aspartate or alanine aminotransferase > 2 times of upper limit of normal), neuromuscular disease
2. Chronic pain problem
3. Prescribed analgesic drugs
4. Contraindication to nefopam such as tachyarrhythmia, pregnancy, convulsive disorder, taking monoamine oxidase inhibitors
5. Allergic to study drugs
6. Unable or refusal to use IV PCA
7. Unable to understand and report numeric rating pain score
8. Anesthetic care personnel plan to do neuraxial or trunk blocks
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Cumulative morphine consumption in 24 hours At 24 hours postoperatively Data from IV PCA machine
- Secondary Outcome Measures
Name Time Method Postoperative pain score At 0, 1, 6, 12, 24, 48 hours postoperatively Numeric rating scale,Incidence of adverse effects During 24 hours postoperatively Dry mouth, profuse sweating, nausea, and vomiting