NL-OMON56151招募中2 期
Programmed death ligand 1 (PD-L1) PET imaging in patients with (Diffuse) Large B-cell lymphoma who are treated with CD19-directed CAR T-cell therapy: a pilot study. - PD-L1 PET-imaging during CAR T-cell therapy
适应症
试验速览
- 阶段
- 2 期
- 状态
- 招募中
- 入组人数
- 20
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Interventional
入排标准
- 年龄范围
- 18 至 99（—）
入选标准
- •1. Histologically confirmed LBCL and associated subtypes, defined by WHO 2016
- •classification
- •2. Eligibility for CAR T-cell therapy must be approved by the Dutch National
- •Tumor Board.
- •3. Measurable disease, as defined by Lugano criteria
- •4. Signed informed consent.
- •5. Age >=18 at the time of signing informed consent.
- •6. Ability to comply with the protocol.
排除标准
- •1.Signs or symptoms of active infection within 2 weeks prior to
- •89Zr-atezolizumab injection, unless treated to resolution.
- •2.History of severe allergic, anaphylactic, or other hypersensitivity reactions
- •to chimeric or humanized antibodies or fusion proteins.
- •3.Any other diseases, metabolic dysfunction, physical examination finding, or
- •clinical laboratory finding giving reasonable suspicion of a disease or
- •condition that contraindicates the use of 89Zr-atezolizumab, or that may affect
- •the interpretation of the results or render the patient at high risk from
- •complications.
研究者
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