Protein acetylation as a diet-modifiable biomarker of colorectal cancer risk

Not Applicable

Completed

• Conditions: Colorectal cancer/bowel health; Cancer; Malignant neoplasm of rectosigmoid junction

• Registration Number: ISRCTN90852168
• Lead Sponsor: niversity of Sheffield (UK)

Brief Summary

2009 protocol in https://www.ncbi.nlm.nih.gov/pubmed/19765278 2015 results in https://www.ncbi.nlm.nih.gov/pubmed/26462274

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2009-08-04
• Study Completion: 2009-09-30
• Last Update Posted: 12 February 2018

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 140

Inclusion Criteria

1. Aged 40 years and above, either sex for interventional arm and male only for cross-sectional arm
2. Adenoma, normal or cancer colon (30 of each group)
3. Body mass index (BMI) between 20 and 29 kg/m^2; 1. Aged 40 years and above, either sex for interventional arm and male only for cross-sectional arm
2. Adenoma, normal or cancer colon (30 of each group)
3. Body mass index (BMI) between 20 and 29 kg/m^2

Exclusion Criteria

1. Severe medical or psychiatric illness
2. Unable to understand or communicate effectively; 1. Severe medical or psychiatric illness
2. Unable to understand or communicate effectively

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Altered faecal short chain fatty acid (SCFA) production.<br><br>In the cross-sectional arm there is a single sampling timepoint and all primary and secondary measures are made at this point. For the intervention arm sampling is performed at baseline and after 8 weeks of intervention.;Altered faecal short chain fatty acid (SCFA) production.<br><br>In the cross-sectional arm there is a single sampling timepoint and all primary and secondary measures are made at this point. For the intervention arm sampling is performed at baseline and after 8 weeks of intervention.

Secondary Outcome Measures

Name	Time	Method
1. Altered bowel crypt cytokinetics (proliferation, apoptosis and apoptosis regulators)<br>2. Identification of candidate biomarker acetylations<br><br>In the cross-sectional arm there is a single sampling timepoint and all primary and secondary measures are made at this point. For the intervention arm sampling is performed at baseline and after 8 weeks of intervention.;1. Altered bowel crypt cytokinetics (proliferation, apoptosis and apoptosis regulators)<br>2. Identification of candidate biomarker acetylations<br><br>In the cross-sectional arm there is a single sampling timepoint and all primary and secondary measures are made at this point. For the intervention arm sampling is performed at baseline and after 8 weeks of intervention.