Preoperative Oral Carbohydrate Treatment Minimizes Insulin Resistance
- Conditions
- Insulin Resistance
- Interventions
- Dietary Supplement: Preoperative Oral Carbohydrate Drink
- Registration Number
- NCT03658564
- Brief Summary
Insulin resistance is a positive protective reaction against surgery .this resistance has some negative consequences for patient health. It is associated with infectious complications. At the same time, Postoperative insulin resistance has been shown to correlate with the length of postoperative stay in hospital. Recently several clinical studies have shown that a carbohydrate-rich drink given 2 h before surgery diminishes postoperative insulin resistance in patient. The aim of our study is to investigate the influence on insulin resistance in patient with diabetes.
- Detailed Description
Insulin resistance is a positive protective reaction against surgery . As a response to surgery, activation of neuroendocrine and inflammation systems occurs as a protective reaction. However, this resistance has some negative consequences for patient health. It is associated with infectious complications. At the same time, Postoperative insulin resistance has been shown to correlate with the length of postoperative stay in hospital. Recently several clinical studies have shown that a carbohydrate-rich drink given 2 h before surgery diminishes postoperative insulin resistance in patient. The aim of our study is to investigate the influence on insulin resistance in patient with diabetes.
Recruitment & Eligibility
- Status
- UNKNOWN
- Sex
- All
- Target Recruitment
- 80
- patients underwent elective open colorectal resection for colorectal carcinoma and electric orthopedic surgery
- Weight loss greater than 10 per cent during the previous 6 months
- Renal insufficiency (creatinine, > 3 mg/dl; hemodialysis)
- Hepatic insufficiency (Child-Pugh class, ≥ B)
- Gastro-oesophageal reflux disease
- Gastrointestinal obstruction or conditions (including pharmacological treatment) known to affect gastric emptying rate
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description Oral carbohydrate Preoperative Oral Carbohydrate Drink fast from midnight the night before surgery, and patients consume 400 ml Preoperative oral carbohydrate preOp®(12.5% carbohydrates, 0.5%kcal/ml, 240 mOsm, pH 4.9, Nutricia Zoetermeer, the Netherlands) 3 hours prior to induction of anesthesia and finished the ingestion within 20 minutes.
- Primary Outcome Measures
Name Time Method VAS 1 day (preoperative period) Preoperative general well-beings before assessed with the visual analogue scale (VAS).
- Secondary Outcome Measures
Name Time Method HOMA perioperative period) Preoperative insulin resistance before and immediately after the surgery assessed with the homeostasis model assessment (HOMA)
Trial Locations
- Locations (1)
The Second Hospital of Dalian Medical University
🇨🇳Dalian, Liaoning, China