DRKS00008981招募中不适用
The role of heme oxygenase 1 (HO-1) for hematoma resolution, neuroinflammation, circadian rhythm and clinical outcome after hemorrhagic or traumatic brain injury - The role of heme oxygenase 1 in brain injury
niversitätsklinik Freiburg, Klinik für Anästhesiologie und Intensivmedizin0 个研究点目标入组 190 人开始时间: 2015年7月31日最近更新:
适应症
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 发起方
- 入组人数
- 190
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Observational
入排标准
- 年龄范围
- 18 Years 至 one（—）
- 性别
- All
入选标准
- •SAH patients:
- •1. Adults (> 18 years) male or female persons.
- •2. Detection of SAH by imaging or in the cerebrospinal fluid (lumbar puncture with blood / xanthochromia).
- •3. Admission to the Freiburg University Hospital within 24 hours of the onset of symptoms.
- •4. Surgical therapeutic intervention with placement of an EVD / lumbar drainage and a CVC / arterial catheter.
- •5. Ability to consent, either personally or through an authorized person.
- •Polytrauma +/- traumatic brain injury:
- •1. Adult patients with polytrauma (ISS> 16) +/- traumatic brain injury
- •2. Admission to the anesthetic intensive care unit within 24 hours after trauma
- •3. Ability to consent either in person or by proxy.
- •Severe traumatic brain injury:
- •1. Adult patients with severe traumatic brain injury (initial point value Glasgow coma scale <8)
- •2. Admission to the anaesthesiological intensive care unit or neurosurgical intensive care unit within 24 hours after trauma
- •3. Establishment of an intravascular catheter (arterial line, peripheral or central venous line) within 24 hours after trauma for therapeutic / diagnostic purposes
- •4. Ability to consent through proxy
排除标准
- •SAH patients:
- •1. Children <18 years.
- •2. Recording later than 24 hours after the onset of symptoms.
- •3. The patient dies within 24 hours of admission.
- •4. Radiographic suspicion of additional subdural or epidural bleeding.
- •5. Radiographic suspicion of meningitis or encephalitis.
- •6. pregnant patients.
- •7. Patients with sepsis, SIRS or other systemic inflammation symptoms.
- •8. Patients with pre-existing intellectual disabilities.
- •Polytrauma patients:
- •1. pre-existing kidney damage / impaired kidney function
- •2. Not taken within 24 hours after trauma
- •3. Die within 24 hours of admission
- •4. Traumatic or non-traumatic brain damage within the past
- •Patients with severe TBI:
- •1. Not taken within 24 hours after trauma
- •2. Die within 24 hours of admission
- •3. Traumatic or non-traumatic brain damage within the past
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