We Walk - Energy Expenditure and Health Outcomes in Older, Sedentary Women.
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 72
- 试验地点
- 2
- 主要终点
- Change from baseline total daily energy expenditure and its components (resting metabolic rate, thermic effect of food, non-exercise activity thermogenesis)in 4 months
研究概览
简要总结
The overall goal is to determine whether any energy expenditure compensation in response to 16 weeks of aerobic exercise at a higher-dose is greater compared to a lower-dose intervention in older women, and to begin to investigate underlying physiological mechanisms that influence energy expenditure changes in older women.
详细描述
The overall goal is to determine whether any energy expenditure compensation in response to 16 weeks of aerobic exercise at a higher-dose is greater compared to a lower-dose intervention in older women, and to begin to investigate underlying physiological mechanisms that influence energy expenditure changes in older women. Changes in all components of energy expenditure, as well as concentrations of plasma leptin and serum free T3, in response to the two different exercise programs (14 and 8 kcal/kg body weight weekly, 60-65% VO2max, 4 days/wk) will be compared in older, non-obese women (60-75 yrs, BMI=18-30 kg/m2).
Specific Aim 1: To determine whether differential changes in total daily energy expenditure and its components occur in older women in response to two exercise programs of different doses. State-of-the-art methods will be used (total daily energy expenditure by doubly labeled water; non-exercise activity thermogenesis using Physical Activity Monitoring System; resting metabolic rate and thermic effect of food via indirect calorimetry).
Primary Hypothesis: Due to a greater decline in NEAT, women will exhibit a smaller increase in total daily energy expenditure in response to the higher-dose, compared to the lower-dose, exercise program, despite greater increases in resting metabolic rate and thermic effect of food.
Specific Aim 2: To explore whether differential changes occur in plasma leptin and serum free triiodo-L-thyronine (free T3) concentrations in older women in response to 16-week aerobic exercise programs of two different doses.
We hypothesize that in response to the higher-dose exercise program, women will exhibit larger decreases in plasma leptin and serum free T3 concentrations, compared to the lower-dose exercise program.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Supportive Care
- 盲法
- None
入排标准
- 年龄范围
- 60 Years 至 75 Years（Adult, Older Adult）
- 性别
- Female
- 接受健康志愿者
- 是
入选标准
- •BMI 18-30
- •Sedentary (exercising less than 20 minutes no more than 3 times per week)
- •Non-smoking
- •Weight stable (+/- 5%) over past 3 months
排除标准
- •Self-reported cardiovascular disease
- •Additional self-reported medical conditions
- •Medications known to affect metabolism
- •Excess caffeine use
- •Self-reported contradictions according to ACSM
- •Unwillingness to provide informed consent
研究组 & 干预措施
Low Dosage
Exercise dose of 8kcal/kg/week
干预措施: Low Dosage (Behavioral)
High Dosage
Exercise dose 14kcal/kg/week
干预措施: High Dosage (Behavioral)
结局指标
主要结局
Change from baseline total daily energy expenditure and its components (resting metabolic rate, thermic effect of food, non-exercise activity thermogenesis)in 4 months
时间窗: Baseline (pre-intervention); 4 months (post-intervention)
次要结局
- Change from baseline plasma leptin and serum free triiodo-L-thyronine (free T3) concentrations in 4 months(Baseline (pre-intervention); 4 month (post-intervention))
研究者
Xuewen Wang
Assistant Professor
University of South Carolina