Energy Expenditure & Activity During & After Exercise-Induced Weight Loss

Not Applicable

Completed

• Conditions: Obesity

• Registration Number: NCT00622310
• Lead Sponsor: University of Colorado, Denver

Brief Summary

This project is aimed at determining whether an exercise-based weight loss intervention causes a compensation in some component of energy expenditure such that the increase in measured energy expenditure is less than the added exercise. The study will compare two separate exercise interventions to determine if this is influenced by exercise intensity.

Detailed Description

The primary aim of this proposed study is to determine how total daily activity thermogenesis (TDAT) and total daily energy expenditure (TDEE) are regulated in obese humans attempting to lose weight and maintain weight loss through exercise. Two exercise interventions will be compared; a structured aerobic exercise program and a walking program. exercise activity thermogenesis (EAT) will be verified, and non-exercise physical activity (NEAT), total daily activity thermogenesis (TDAT), and TDEE will be measured using state-of-the-art technologies. Subjects will be studied during a 6 month intervention period and then during a 6 month follow-up period. It is hypothesized that the walking program will have more favorable effects on TDAT and TDEE during both the intervention and follow-up periods. If the investigators hypotheses are correct, then data from the proposed study could be used to improve the effectiveness of exercise-based weight loss and weight loss maintenance programs.

Study Timeline

• Study Start: 2007-09
• Study First Submitted: 2008-02-21
• Study First Submitted QC: 2008-02-21
• Study First Posted: 2008-02-25
• Primary Completion: 2008-06
• Study Completion: 2008-06
• Status Verified: 2021-07
• Last Update Submitted: 2021-07-06
• Last Update Posted: 2021-07-12

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 30

Inclusion Criteria

Not provided

Exclusion Criteria

• Claustrphobia;
• Any contraindication(s) to > MRI, e.g. aneurysm, cochlear implant, cardiac pacemaker, or implantable cardiac defibrillator, artificial heart valve, metallic stents, any implantable devices or shunt, weight less than 300 lbs;
• Left Handed.

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Primary Outcome Measures

Name	Time	Method
Total daily energy expenditure, assessed using doubly labeled water	Prior to exercise intervention, and 6 months

Secondary Outcome Measures

Name	Time	Method
Total daily activity thermogenesis	Prior to exercise intervention, and 6 months
Body weight and composition	Prior to exercise intervention, and 6 months

Trial Locations

Locations (1)

University of Colorado, School of Medicine; 🇺🇸 Aurora, Colorado, United States