Additional Metabolic and Vascular Effects of Exercise in Patients on Diet-based Weight Loss Programs
- Conditions
- Obesity
- Registration Number
- NCT00929890
- Lead Sponsor
- Hospital de Clinicas de Porto Alegre
- Brief Summary
This study tests the hypothesis that exercise training can confer additional benefit to patients in weight-loss programs in the form of improvements in either metabolic or vascular parameters or both. Patients will be randomized to either diet plus conventional physical activity or diet plus a planned exercise training. The interventions will be carried out until the patients lose between 5% and 7.5% of their initial weight. At entry and at the end, all subjects will be evaluated for outcomes such as blood glucose, lipid profile, insulin, c-reactive protein, fibrinogen, vascular reactivity (doppler ultrasound) and total and abdominal visceral fat (CT-scan). Both groups will be compared.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- UNKNOWN
- Sex
- All
- Target Recruitment
- 50
- BMI> 30 and <40
- Diabetes mellitus
- Active endocrine disease
- Active heart disease
- Active smoking
- Medical contra-indications for exercise
- Using anti-obesity drugs
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Primary Outcome Measures
Name Time Method Reduction in homeostasis model assessment of insulin resistance (HOMA-IR) 6 months Change in lipid profile 6 months Reduction in abdominal (visceral) fat 6 months Change in vascular reactivity 6 months
- Secondary Outcome Measures
Name Time Method C-reactive protein 6 months Fibrinogen 6 months vonWillebrand factor 6 months Waist circumference 6 months
Trial Locations
- Locations (1)
Hospital de Clínicas de Porto Alegre
🇧🇷Porto Alegre, RS, Brazil
Hospital de Clínicas de Porto Alegre🇧🇷Porto Alegre, RS, Brazil