Exercise and Weight Control: A Search for Biological and Neurobehavioral Compensatory Mechanisms That Defend Against Exercise-Induced Negative Energy Balance

USDA Grand Forks Human Nutrition Research Center1 site in 1 country29 target enrollmentApril 2016

ConditionsOverweight Obese

Overview

Phase: Not Applicable
Intervention: Not specified
Conditions: Overweight
Sponsor: USDA Grand Forks Human Nutrition Research Center
Enrollment: 29
Locations: 1
Primary Endpoint: Negative Energy Balance as assessed by changes in adipose tissue
Status: Completed
Last Updated: last year

Overview Investigators Eligibility Criteria Outcomes Sites Similar Trials

Overview

Brief Summary

The purpose of this study is to research the effects of exercise on calories eaten and expended. The investigator expects to find out whether subjects change their eating and activity behaviors when starting an exercise program.

Registry

clinicaltrials.gov

Start Date

April 2016

End Date

January 2017

Last Updated

last year

Study Type

Interventional

Study Design

Parallel

Sex

All

Investigators

Sponsor

USDA Grand Forks Human Nutrition Research Center

Responsible Party

Sponsor

Eligibility Criteria

Inclusion Criteria

•18 to 40 years old
•BMI of 25.0 - 35 kg/m2
•willing to consent to study conditions
•not taking medications that affects energy expenditure or eating
•not using tobacco or nicotine products
•no food allergies or limitations to eating certain food that would prohibit them from eating the study foods
•not be dieting to lose weight
•no major health problems
•cannot have known cardiovascular, pulmonary or metabolic disease
•cannot be regularly exercising in an aerobic manner more than twice per week

Exclusion Criteria

•\< 18 or \> 40 years old
•BMI \< 25 or \>35 kg/m2
•currently pregnant or trying to become pregnant, or lactating
•currently using tobacco or nicotine
•taking medication that affects energy expenditure or eating
•food allergies to foods used in the study
•regularly exercising in an aerobic manner more than twice per week
•major health problems

Outcomes

Primary Outcomes

Negative Energy Balance as assessed by changes in adipose tissue

Time Frame: End Training (weeks 10-12)

Whether participants were able to maintain a negative energy balance will be assessed by pre-post changes in stored adipose tissue, as assessed by a dual-energy x-ray absorptiometry scan (DEXA).

Secondary Outcomes

Average daily calories consumed as assessed by dietary recall(Pre-intervention (week 0) and End Training (weeks 10-12))
Pre-post intervention changes in Ghrelin plasma levels(Pre-intervention (week 0) and End Training (weeks 10-12))
Pre-post intervention changes in glucagon-like peptide 1 (GLP-1) plasma levels(Pre-intervention (week 0) and End Training (weeks 10-12))
Pre-post intervention changes in Ghrelin concentrations(Pre-intervention (week 0) and End Training (weeks 10-12))
Pre-post intervention changes in irisin concentrations(Pre-intervention (week 0) and End Training (weeks 10-12))
Pre-post intervention changes in myostatin plasma levels(Pre-intervention (week 0) and End Training (weeks 10-12))
Change in relative reinforcing value (RRV) of physical activity(Pre-intervention (week 0) and End Training (weeks 10-12))
Change in minutes of sedentary behavior, as assessed by activity tracker(Pre-intervention (week 0) and End Training (weeks 10-12))
Change in relative reinforcing value (RRV) of food(Pre-intervention (week 0) and End Training (weeks 10-12))