Comparison of the Effect Site Concentration of Remifentanil for Preventing Cough During Emergence Between Male and Female Patients With Thyroidectomy

Not Applicable

Completed

• Conditions: Patients Undergoing Thyroidectomy
• Interventions: Drug: up-and-down method to find out effective concentration of remifentanil for preventing cough during emergence

• Registration Number: NCT01614535
• Lead Sponsor: Yonsei University

Brief Summary

The clinical studies demonstrate more powerful analgesic effect among female to both μ- and κ-opioid agonist (Fillingim et al. 2004). The antitussive effect of opioid is mediated predominantly by μ-, κ-opioid receptors (Kamei J. 1996). Therefore, the investigators hypothesized that there are sex differences in the antitussive responses to opioid.

It has been reported that target-controlled infusion (TCI) of remifentanil can reduce cough against endotracheal tube during emergence from general anesthesia. Some studies, reporting the EC50 and EC95 of remifentanil in effect-site TCI for preventing cough during emergence in different sex and surgeries (B. Lee et al. 2009, E.M.Choi et al. 2012), showed differences in EC50 and EC95.

The purpose of this study was to find out EC50 and EC95 of remifentanil in effect-site TCI for preventing cough during emergence in each sex and to evaluate whether there were sex differences in EC50 and EC95 of remifentanil in effect-site TCI or not.

Detailed Description

Not available

Study Timeline

• Study Start: 2011-08
• Primary Completion: 2012-03
• Study Completion: 2012-03
• Status Verified: 2012-06
• Study First Submitted: 2012-06-03
• Study First Submitted QC: 2012-06-07
• Last Update Submitted: 2012-06-07
• Study First Posted: 2012-06-08
• Last Update Posted: 2012-06-08

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 46

Inclusion Criteria

• aged 20-46
• ASA classification I~II
• patients undergoing thyroidectomy

Exclusion Criteria

• patient who has signs of a difficult airway
• patient who has smoking history
• patient who has upper respiratory infection or sore throat in the previous two weeks
• patient who has hypertension, DM
• female patients who were pregnant, breast-feeding or menopausal

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Female group	up-and-down method to find out effective concentration of remifentanil for preventing cough during emergence	Female gender patients undergoing thyroidectomy
Male group	up-and-down method to find out effective concentration of remifentanil for preventing cough during emergence	Male gender patients undergoing thyroidectomy

Primary Outcome Measures

Name	Time	Method
occurrence of cough	20 minutes after sevoflurane off	The cough was defined as a sudden contraction of the abdomen. The level of cough was assessed and recorded by the following cough grading system: Grade 0, no cough; Grade 1, single cough with mild severity; Grade 2, cough persistence less than 5 sec with moderate severity; Grade 3, severe, persistent cough for more than 5 sec.; The patients will be followed from Sevolurane off to being transported to PACU.

Trial Locations

Locations (1)

Department of Anesthesiology and Pain Medicine; 🇰🇷 Seoul, Korea, Republic of