The Effect of Unfavorable Histological Features on the Oncological Outcomes of Colon Cancer

• Conditions: Colon Cancer

• Registration Number: NCT03794193
• Lead Sponsor: Peking Union Medical College Hospital

Brief Summary

To explore the effect of unfavorable histological features on the clinical outcomes of patients receiving radical resection of colon cancer.

Detailed Description

Not available

Study Timeline

• Study Start: 2016-01-01
• Study First Submitted: 2018-09-09
• Study First Submitted QC: 2019-01-03
• Study First Posted: 2019-01-04
• Primary Completion: 2020-12
• Status Verified: 2022-04
• Last Update Submitted: 2022-04-28
• Last Update Posted: 2022-05-04
• Study Completion: 2023-12

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 1367

Inclusion Criteria

1. Age: 18-100 years old;
2. Postoperative pathology confirmed colon adenocarcinoma;
3. The tumor is located from the cecum to the sigmoid colon;
4. No distant organ metastasis;

Exclusion Criteria

1. Simultaneous or metachronous multiple primary colorectal cancer;
2. History of previous malignant tumors (except for completely cured cervical carcinoma in situ or basal cell carcinoma or squamous epithelial skin cancer)
3. local excision procedure;
4. palliative resection (R2 resection);
5. pregnant or lactating women.

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
3-year Disease-free Survival	Within 3 years after surgery	The time from the time of surgery to the time of recurrence or death from any cause, calculated on a monthly basis, with the most recent recurrence and metastasis.

Secondary Outcome Measures

Name	Time	Method
Postoperative complication rate	Within 30 days after surgery
Postoperative mortality rate	Within 30 days after surgery
Distant organ metastasis rate	Within 3 years after surgery
3-year Over-all Survival	Within 3 years after surgery	The time from the time of surgery to the time of recurrence or death from any cause, calculated on a monthly basis.
Local recurrence rate	Within 3 years after surgery