Activity of stress-related systems, metabolic consequences and genetics of restless legs syndrome, periodic limb movements, parasomnias, narcolepsy and healthy controls
Recruiting
- Conditions
- F51.0G25.8Other specified extrapyramidal and movement disordersG47.4Nonorganic insomniaNarcolepsy and cataplexy
- Registration Number
- DRKS00008902
- Lead Sponsor
- Zentralinstitut für Seelische Gesundheit
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- All
- Target Recruitment
- 1000
Inclusion Criteria
patients with sleep disorder (see above) that is confirmed by polysomnography
Exclusion Criteria
inability to consent
Study & Design
- Study Type
- observational
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Endpoints are metabolic features (cholesterol, fasting glucose etc.) and endocrinological parameters (adipokines, BDNF and others) in blood samples that are collected in the framework of a clinical routine blood withdrawal. Relevant endpoints are laboratory features of the metabolic syndrome (triglycerides, LDL-, HDL- and total cholesterol, fasting glucose) as well as endocrinological variables like adipokines (proteins secreted by fat tissue like leptin, adiponektin) and growth factors, like insulin-like growth factor-1 (IGF-1) and brain-derived neurotrophic factor (BDNF). Cortisol in night urine is an independent variable, which - as well as polysomnography and clinical diagnoses - is relevant for the determination of study groups.
- Secondary Outcome Measures
Name Time Method