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Activity of stress-related systems, metabolic consequences and genetics of restless legs syndrome, periodic limb movements, parasomnias, narcolepsy and healthy controls

Recruiting
Conditions
F51.0
G25.8
Other specified extrapyramidal and movement disorders
G47.4
Nonorganic insomnia
Narcolepsy and cataplexy
Registration Number
DRKS00008902
Lead Sponsor
Zentralinstitut für Seelische Gesundheit
Brief Summary

Not available

Detailed Description

Not available

Recruitment & Eligibility

Status
Recruiting
Sex
All
Target Recruitment
1000
Inclusion Criteria

patients with sleep disorder (see above) that is confirmed by polysomnography

Exclusion Criteria

inability to consent

Study & Design

Study Type
observational
Study Design
Not specified
Primary Outcome Measures
NameTimeMethod
Endpoints are metabolic features (cholesterol, fasting glucose etc.) and endocrinological parameters (adipokines, BDNF and others) in blood samples that are collected in the framework of a clinical routine blood withdrawal. Relevant endpoints are laboratory features of the metabolic syndrome (triglycerides, LDL-, HDL- and total cholesterol, fasting glucose) as well as endocrinological variables like adipokines (proteins secreted by fat tissue like leptin, adiponektin) and growth factors, like insulin-like growth factor-1 (IGF-1) and brain-derived neurotrophic factor (BDNF). Cortisol in night urine is an independent variable, which - as well as polysomnography and clinical diagnoses - is relevant for the determination of study groups.
Secondary Outcome Measures
NameTimeMethod
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