Activity of stress-related systems, metabolic consequences and genetics of restless legs syndrome, periodic limb movements, parasomnias, narcolepsy and healthy controls

Recruiting

• Conditions: F51.0; G25.8; Other specified extrapyramidal and movement disorders; G47.4; Nonorganic insomnia; Narcolepsy and cataplexy

• Registration Number: DRKS00008902
• Lead Sponsor: Zentralinstitut für Seelische Gesundheit

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2015-07-13
• Last Update Posted: 19 August 2024

Recruitment & Eligibility

• Status: Recruiting
• Sex: All
• Target Recruitment: 1000

Inclusion Criteria

patients with sleep disorder (see above) that is confirmed by polysomnography

Exclusion Criteria

inability to consent

Study & Design

• Study Type: observational
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Endpoints are metabolic features (cholesterol, fasting glucose etc.) and endocrinological parameters (adipokines, BDNF and others) in blood samples that are collected in the framework of a clinical routine blood withdrawal. Relevant endpoints are laboratory features of the metabolic syndrome (triglycerides, LDL-, HDL- and total cholesterol, fasting glucose) as well as endocrinological variables like adipokines (proteins secreted by fat tissue like leptin, adiponektin) and growth factors, like insulin-like growth factor-1 (IGF-1) and brain-derived neurotrophic factor (BDNF). Cortisol in night urine is an independent variable, which - as well as polysomnography and clinical diagnoses - is relevant for the determination of study groups.