Evaluation of the Roles of Salivary Mitofusin-1 and Mitofusin-2 Levels in Periodontal Disease
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 入组人数
- 81
- 主要终点
- Mitofusin-1 concentration
研究概览
简要总结
The aim of this observational study is to find out whether there is a level difference in salivary mitofusin-1 and mitofusin-2 levels due to changes in periodontal status. The main question it aims to answer is:
- Do salivary mitofusin-1 and mitofusin-2 levels of periodontitis patients differ from healthy patients?
- Could salivary mitofusin-1 and mitofusin-2 levels be biomarkers for periodontal disease?
Biochemical analysis will be performed on saliva samples taken at once from gingivitis or periodontitis patients and healthy individuals who apply to the periodontology clinic, at the initial stage of the treatment. There is no ongoing monitoring or second sampling.
研究设计
- 研究类型
- Observational
- 观察模型
- Other
- 时间视角
- Cross Sectional
入排标准
- 年龄范围
- 18 Years 至 65 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Being between the ages of 18 and
- •Willing to participate in the study and provide a saliva sample.
- •Having a healthy periodontal condition, gingivitis, or periodontitis (Stage 3-4, Grade C).
- •Having fasted from any food or drink (except water) for the past 2 hours prior to providing the saliva sample.
- •Having refrained from brushing teeth or using mouthwash in the past 2 hours prior to providing the saliva sample.
- •Not having any systemic diseases.
- •Not currently taking any medications regularly.
排除标准
- •Having used antibiotics within the last 6 months.
- •Having received periodontal treatment within the last 6 months.
- •Having fewer than 20 teeth (excluding third molars).
- •Having any systemic diseases.
- •Not smoking or having quit at least 5 years ago.
结局指标
主要结局
Mitofusin-1 concentration
时间窗: Up to four weeks from start of work
Mitofusin-1 concentration in saliva, determined as a result of biochemical analysis
Mitofusin-2 concentration
时间窗: Up to four weeks from start of work
Mitofusin-2 concentration in saliva, determined as a result of biochemical analysis
IL-1B concentration
时间窗: Up to four weeks from start of work
IL-1B concentration in saliva, determined as a result of biochemical analysis
次要结局
未报告次要终点
研究者
Ömer Faruk Okumuş
Assistant Professor
Erzincan University