Periodontal Disease and Salivary Mitofusin Levels

Not yet recruiting

• Conditions: Periodontal Diseases; Periodontitis; Gingivitis
• Interventions: Diagnostic Test: Biochemical analysis of saliva sample

• Registration Number: NCT06510608
• Lead Sponsor: Erzincan University

Brief Summary

The aim of this observational study is to find out whether there is a level difference in salivary mitofusin-1 and mitofusin-2 levels due to changes in periodontal status. The main question it aims to answer is:

* Do salivary mitofusin-1 and mitofusin-2 levels of periodontitis patients differ from healthy patients?

* Could salivary mitofusin-1 and mitofusin-2 levels be biomarkers for periodontal disease?

Biochemical analysis will be performed on saliva samples taken at once from gingivitis or periodontitis patients and healthy individuals who apply to the periodontology clinic, at the initial stage of the treatment. There is no ongoing monitoring or second sampling.

Detailed Description

Not available

Basic Information
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Recruitment & Eligibility
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Study & Design

Study Timeline

• Status Verified: 2024-07
• Study First Submitted: 2024-07-05
• Study First Submitted QC: 2024-07-14
• Last Update Submitted: 2024-07-14
• Study First Posted: 2024-07-19
• Last Update Posted: 2024-07-19
• Study Start: 2024-07-25
• Primary Completion: 2024-08-25
• Study Completion: 2024-09-25

Recruitment & Eligibility

• Status: NOT_YET_RECRUITING
• Sex: All
• Target Recruitment: 81

Inclusion Criteria

• Being between the ages of 18 and 65.
• Willing to participate in the study and provide a saliva sample.
• Having a healthy periodontal condition, gingivitis, or periodontitis (Stage 3-4, Grade C).
• Having fasted from any food or drink (except water) for the past 2 hours prior to providing the saliva sample.
• Having refrained from brushing teeth or using mouthwash in the past 2 hours prior to providing the saliva sample.
• Not having any systemic diseases.
• Not currently taking any medications regularly.

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Exclusion Criteria

• Having used antibiotics within the last 6 months.
• Having received periodontal treatment within the last 6 months.
• Having fewer than 20 teeth (excluding third molars).
• Having any systemic diseases.
• Not smoking or having quit at least 5 years ago.

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Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
Healthy	Biochemical analysis of saliva sample	-
Gingivitis	Biochemical analysis of saliva sample	-
Periodontitis	Biochemical analysis of saliva sample	-

Primary Outcome Measures

Name	Time	Method
Mitofusin-1 concentration	Up to four weeks from start of work	Mitofusin-1 concentration in saliva, determined as a result of biochemical analysis
Mitofusin-2 concentration	Up to four weeks from start of work	Mitofusin-2 concentration in saliva, determined as a result of biochemical analysis
IL-1B concentration	Up to four weeks from start of work	IL-1B concentration in saliva, determined as a result of biochemical analysis