NCT01776112已完成不适用
Enhancing Synaptic Plasticity and Cognition by Physical Exercise and Cognitive Training in Schizophrenia: A Randomised Controlled Trial
University Medical Center Goettingen2 个研究点 分布在 1 个国家目标入组 66 人开始时间: 2011年1月1日最近更新:
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 66
- 试验地点
- 2
- 主要终点
- Hippocampal volume
研究概览
简要总结
To explore: (a) if physical exercise (sports) combined with cognitive training leads to (superior) improvement of cognition in schizophrenia compared to sports or cognitive training alone (b) if a sports program alone or in combination with cognitive training has influence on hippocampal pathology and synaptic plasticity in schizophrenia compared to a placebo condition.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Single (Outcomes Assessor)
入排标准
- 年龄范围
- 18 Years 至 55 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Male and female patients with the diagnosis of schizophrenia (based on ICD-10 criteria)
- •Age between 18 and 55
- •Verbal IQ ≥ 85
- •Stable psychopathology on constant medication for 2 weeks
- •Informed consent.
排除标准
- •Patients, who are
- •not willing or able to participate in the sports program and cognitive training
- •reveal a significant worsening of psychopathology (based on an increase over 20% of the PANSS positive score)
- •have an organic mental disorder (such as intoxication or neurological disorders of the CNS)
- •suffer from instable somatic diseases
- •have an active substance abuse
结局指标
主要结局
Hippocampal volume
时间窗: after three months of exercise
Measurement of hippocampal volume before and after the exercise intervention, 3T-MRI MPRAGE-Sequence, manual and automated delineation of hippocampal borders
次要结局
- Verbal Learning Memory(after three months of exercise)
- Positive and negative symptoms(after three months of exercise)
研究者
Prof. Dr. Peter Falkai
Prof. Dr. med. Peter Falkai
University Medical Center Goettingen
研究点 (2)
Loading locations...
相似试验
进行中（未招募）
不适用
Fit Bodies, Fine Minds: Physical activity and cognitive training for cognition in older adultsMemoryExecutive functioningMental speedAerobic fitnessFunctional strengthPsychological well-beingMental Health - Studies of normal psychology, cognitive function and behaviourACTRN12607000151437Siobhan O'Dwyer90
进行中（未招募）
不适用
E-BRAIN Project: Investigating the effect of different forms of physical exercises on the cognition of the elderlyElderly healthM01.060.116.100RBR-8zjf6bniversidade de São Paulo - Escola de educação Física e esporte
Unknown
不适用
Effects of the Physical Activity and Cognitive Training ProgramCognitive DeclineNCT02114125National Taiwan University Hospital270
招募中
不适用
The Effects of Exercise on Synaptic Plasticity in Individuals With Mild Cognitive Impairment and in Healthy Aging.Mild Cognitive ImpairmentNCT05663918McMaster University36
尚未招募
不适用
PAM studyNL-OMON21029niversity Medical Center Utrecht (UMCU)180