Effects of Task-oriented Training on Functional Mobility and Fatigue in Patients With Multiple Sclerosis

Not Applicable

• Conditions: Multiple Sclerosis, Relapsing-Remitting
• Interventions: Other: Combined exercise training; Other: Task-oriented training

• Registration Number: NCT03497468
• Lead Sponsor: Bezmialem Vakif University

Brief Summary

Multiple Sclerosis (MS) is inflammatory, demyelinating and autoimmune disease of the central nervous system. It is usually seen with relapses and genetic and environmental factors play a role in the etiology. Neurological symptoms seen in MS restrict the patient's daily activity and social role participation. Mobility problems and fatigue are the most important reasons of role limitations and decreased quality of life. The importance of exercise training in disease management has been emphasized in recent years. However, few studies have investigated the effects of task-oriented trainings on symptoms of the disease. The aim of this sudy is to investigate the effects of task-oriented training additional to combined exercise training on functional capacity, mobility, balance, fatigue and quality of life in patients with MS.

Detailed Description

Not available

Study Timeline

• Status Verified: 2018-04
• Study Start: 2018-04
• Study First Submitted: 2018-04-03
• Study First Submitted QC: 2018-04-12
• Last Update Submitted: 2018-04-12
• Study First Posted: 2018-04-13
• Last Update Posted: 2018-04-13
• Primary Completion: 2018-06-01
• Study Completion: 2018-06

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 34

Inclusion Criteria

• Multiple Sclerosis diagnosis
• Expanded Disability Status Scale > 5,5
• No cognitive problems
• No relapses in the last 3 months
• No other neurological or chronic disease

Exclusion Criteria

• Relapse during the intervention
• Exercise intolerance

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Control group	Combined exercise training	Patients in this group will receive combined exercise training included aerobic and strengthening exercises, 3 times a week for 6 weeks. All exercise sessions will be performed under the supervision of a physiotherapist.
Training group	Task-oriented training	Patients in this group will receive task-oriented training additional to combined exercise training 3 times a week for 6 weeks. Task-oriented training included more functional daily life mobility activities like reaching, obstacle walking, stairs climbing. All exercise sessions will be performed under the supervision of a physiotherapist.

Primary Outcome Measures

Name	Time	Method
Functional capacity	6 weeks	Change from baseline functional capacity with six minute walking test

Secondary Outcome Measures

Name	Time	Method
dynamic gait skills	6 weeks	Change from baseline functional mobility with dynamic gait index
limitation of gait	6 weeks	Change from baseline functional mobility with MS walking scale-12
dynamic balance and fall risk	6 weeks	Change from baseline functional mobility with timed up and go test
sitatic balance	6 weeks	Change from baseline balance with functional reach test
dynamic balance	6 weeks	Change from baseline balance with berg balance scale
severity of fatigue	6 weeks	Change from baseline fatigue with fatigue severity scale
impact of fatigue	6 weeks	Change from baseline fatigue with fatigue impact scale
Quality of life	6 weeks	Change from baseline quality of life with MS quality of life instrument-54