Enforced Reduction in Physical Activity and Recovery in Older Adults
- Conditions
- Muscle DegenerationBody Weight ChangesWalking, Difficulty
- Registration Number
- NCT04997447
- Lead Sponsor
- University of Jyvaskyla
- Brief Summary
Apparently healthy and well-functioning community dwelling 70-80 year-olds will be recruited to the study. All subjects undergo pre-screening for suitability and a physicians examination, as well as 7-day habitual daily steps are measured to ascertain baseline physical activity. Half of the recruited subjects (n=40) will be randomized into the intervention group and half (n=40) randomized into the control group. The intervention group is then required to reduce their daily steps to \<2000 for a 2-week period. Thereafter, the intervention group participates to a 4-week strength+endurance training rehabilitation program and no longer has restricted daily step count. The control group continues their normal habitual physical activity level throughout the 6-week study period.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 66
- aged 70-80 years,
- community-dwelling,
- able to walk 500 m without assistance or use of walking aid and regularly walking >5000 steps per day,
- MMSE >24,
- BMI 20-35 kg·m2 (i.e. not underweight or severely obese),
- no serious cardiovascular or musculoskeletal disease,
- no risk factors for deep-vein thrombosis (e.g. blood clotting disorder, obesity, bowel diseases, personal or family history of DVT etc.),
- non-smoker,
- provision of informed consent.
- Underlying diseases likely to limit lifespan and/or intervention safety. Contraindication for physical exercise or physical tests identified during physician's examination,
- unwilling/unable to track daily step counts using accelerometer,
- excessive and regular use of alcohol (more than 7 units per week for women and 14 for men)
- difficulty in communication due to severe vision or hearing problems
- unwilling to provide consent or accept randomization into either study group
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Primary Outcome Measures
Name Time Method Lean leg mass 6 weeks DXA-measured total lean mass of the legs
- Secondary Outcome Measures
Name Time Method Walking economy 6 weeks Oxygen uptake while walking at 3 and 5 km.h-1
Whole-body fat mass 6 weeks DXA-measured total body fat mass
Maximum isometric leg extension force 6 weeks Maximum strength of legs
Short Physical Performance Battery (SPPB) 6 weeks Walking, balance and chair-rise tests
Blood pressure 6 weeks Systolic and diastolic blood pressure during rest (sitting)
HOMA indices 6 weeks Blood glucose and insulin concentration based calculations related to insulin resistance and beta-cell function
White blood cell respiration 6 weeks Isolated white blood cell respiration as a marker for mitochondrial function
Related Research Topics
Explore scientific publications, clinical data analysis, treatment approaches, and expert-compiled information related to the mechanisms and outcomes of this trial. Click any topic for comprehensive research insights.
Trial Locations
- Locations (1)
University of Jyväskylä
🇫🇮Jyväskylä, Central Finland, Finland
University of Jyväskylä🇫🇮Jyväskylä, Central Finland, Finland