Enforced Reduction in Physical Activity and Recovery in Older Adults
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 66
- 试验地点
- 2
- 主要终点
- Lean leg mass
研究概览
简要总结
Apparently healthy and well-functioning community dwelling 70-80 year-olds will be recruited to the study. All subjects undergo pre-screening for suitability and a physicians examination, as well as 7-day habitual daily steps are measured to ascertain baseline physical activity. Half of the recruited subjects (n=40) will be randomized into the intervention group and half (n=40) randomized into the control group. The intervention group is then required to reduce their daily steps to <2000 for a 2-week period. Thereafter, the intervention group participates to a 4-week strength+endurance training rehabilitation program and no longer has restricted daily step count. The control group continues their normal habitual physical activity level throughout the 6-week study period.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Basic Science
- 盲法
- None
入排标准
- 年龄范围
- 70 Years 至 80 Years（Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •aged 70-80 years,
- •community-dwelling,
- •able to walk 500 m without assistance or use of walking aid and regularly walking >5000 steps per day,
- •BMI 20-35 kg·m2 (i.e. not underweight or severely obese),
- •no serious cardiovascular or musculoskeletal disease,
- •no risk factors for deep-vein thrombosis (e.g. blood clotting disorder, obesity, bowel diseases, personal or family history of DVT etc.),
- •non-smoker,
- •provision of informed consent.
排除标准
- •Underlying diseases likely to limit lifespan and/or intervention safety. Contraindication for physical exercise or physical tests identified during physician's examination,
- •unwilling/unable to track daily step counts using accelerometer,
- •excessive and regular use of alcohol (more than 7 units per week for women and 14 for men)
- •difficulty in communication due to severe vision or hearing problems
- •unwilling to provide consent or accept randomization into either study group
结局指标
主要结局
Lean leg mass
时间窗: 6 weeks
DXA-measured total lean mass of the legs
次要结局
- Walking economy(6 weeks)
- Whole-body fat mass(6 weeks)
- Maximum isometric leg extension force(6 weeks)
- Short Physical Performance Battery (SPPB)(6 weeks)
- Blood pressure(6 weeks)
- HOMA indices(6 weeks)
- White blood cell respiration(6 weeks)