The Effect of Oral Carnosine Supplementation on Urine Microalbumin in Diabetic Nephropathy: A Randomized Controlled Trial
Phase 3
Recruiting
- Conditions
- diabetic nephropathycarnosineurine microalbuminurine TGF-b
- Registration Number
- TCTR20220226002
- Lead Sponsor
- Division of Nephrology, Department of Medicine, Phramongkutklao Hospital and College of Medicine, Bangkok, Thailand
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- All
- Target Recruitment
- 78
Inclusion Criteria
age of 18 years old or older
urine albumin-creatinine ratio
(UACR) of 30 to 299 mg/g creatinine (Cr)
stable dose of ACEIs or ARBs at least 3 months
stable hemoglobinA1C (HbA1C) within 3 months
Exclusion Criteria
active infections
CKD from nondiabetic cause
advanced malignancy
history of hypersensitivity to protein nutrients
problems with nutrient absorption of the gastro-intestinal tract
liver disease
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method urine microalbumin at 12 weeks after intervention UACR
- Secondary Outcome Measures
Name Time Method urine TGF-Beta at 12 weeks after intervention ELISA