Effect of Combined Anodal TDCS and Peripheral Nerve Stimulation on Motor Recovery in Acute Stroke
Overview
- Phase
- Phase 2
- Intervention
- Not specified
- Conditions
- Acute Ischaemic Stroke
- Sponsor
- Institut National de la Santé Et de la Recherche Médicale, France
- Enrollment
- 20
- Locations
- 1
- Primary Endpoint
- Jebsen Taylor test
- Status
- Completed
- Last Updated
- last year
Overview
Brief Summary
Recent work showed that application of peripheral nerve and cortical stimulation independently can induce 10-15 % improvement in motor performance in patients with chronic stroke.
The purpose of this study was to compare in post-stroke hemiplegic patients the effect on motor recovery of one session of anodal transcranial direct current stimulation to the ipsilesional primary motor cortex (M1) combined with a peripheral radial nerve electrical stimulation (rEPNS) to the paretic hand repeated 5 successive days with the effect of the same peripheral nerve stimulation combined with sham tDCS.
Design: randomized, double-blind, parallel controlled clinical trial. Patients eligible for the study: Acute ischaemic stroke Primary outcome measure: Jebsen Taylor test Secondary outcome measures Nine peg hole test Hand tapping grip and wrist force Cortical excitability of Ipsilesional M1(TMS) Follow-up: 30 days
Investigators
Eligibility Criteria
Inclusion Criteria
- •first -ever ischemic stroke within 5-30 days a paresis of the arm/hand with NIHSS \<15 age 35-85 years
Exclusion Criteria
- •Pregnancy psychiatric disease patients with history of alcohol or drug abuse or severe depression patients with a severe language disturbances, particularly of receptive nature patients with increased intracranial pressure or serious cardiac disease patients with contraindication to TMS
Outcomes
Primary Outcomes
Jebsen Taylor test
Time Frame: 5-15-30 days
Secondary Outcomes
- Grip and wrist force Nine peg hole Cortical excitability ofIpsilesional M1 (TMS)(5-15-30 days)