Visual Mode Switching in Color Perception

Not Applicable

Not yet recruiting

• Conditions: Perception of Things Changing Color; Adaptive Behavior
• Interventions: Behavioral: Mode Switching Training

• Registration Number: NCT05779228
• Lead Sponsor: University of Minnesota

Brief Summary

Participants will be given experience wearing colored lenses that add a tint to the environment. Changes in visual perception and neural processing that arise as a result of this experience will be measured. These are expected as participants learn to switch to "colored lenses mode" where the effects of the lenses are discounted and colors appear more normal as soon as the lenses are put on.

Detailed Description

All participants will wear tinted lenses for 1 hour at a time, 5 times per day. Perception (behavior) and neural function (with functional MRI and EEG) before and after this experience will be measured. In the neural measurements, activity will be recorded while participants view stripes of many different colors both with the lenses on and off. In the perceptual measurements, participants will adjust the color of a small patch to appear neutral, neither red nor green. Behavior will be measured in a variety of conditions to test different hypotheses about the origins of the mode-switching effects. These include: 1) surrounding the patch with different colors, 2) preceding the presentation of the patch with presentation of different colors, 3) presenting the tests in a red-illuminated room, 4) presenting the tests in a completely darkened room, and 5) using a head-mount-display (virtual reality goggles) to present simulated lenses that gradually change in strength.

Study Timeline

• Study First Submitted: 2023-01-20
• Study First Submitted QC: 2023-03-18
• Study First Posted: 2023-03-22
• Status Verified: 2025-03
• Last Update Submitted: 2025-03-03
• Last Update Posted: 2025-03-04
• Study Start: 2026-01-01
• Primary Completion: 2031-02-04
• Study Completion: 2032-02-04

Recruitment & Eligibility

• Status: NOT_YET_RECRUITING
• Sex: All
• Target Recruitment: 75

Inclusion Criteria

• Normal or corrected to normal vision by contact lenses
• No known visual disorders
• Little to no experience in tinted environments (e.g. dark rooms, swimming goggles)

Exclusion Criteria

• Abnormal color vision

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Color Adaptation	Mode Switching Training	Test patch is surrounded temporally (preceded) by different colors
Neuroimaging	Mode Switching Training	Functional MRI and Electroencephelography data are acquired for multiple test colors
Color Contrast	Mode Switching Training	Test patch is surrounded spatially by different colors
Red Room	Mode Switching Training	Participants are tested in a red-illuminated room
Dark Room	Mode Switching Training	Participants are tested in a completely darkened room
Gradual Change	Mode Switching Training	Participants view a gradual change in tint, presented on a head-mounted display

Primary Outcome Measures

Name	Time	Method
Change in EEG activity	Change will be assessed over the entire study, by comparing a pre-test the day before the intevention (which lasts 5 days) to a post-test the day after the intervention.	Neural activity will be measured with electroencephelography using standard techniques and will be reported as voltage changes over time for each electrode in a standard configuration.
Change in BOLD functional MRI activity	Change will be assessed over the entire study, by comparing a pre-test the day before the intevention (which lasts 5 days) to a post-test the day after the intervention.	Neural activation will be measured with functional MRI which will be used to measure BOLD activity with standard methods, and reported as percent change from rest, a standard measure, for each voxel in the brain.
Change in unique yellow settings	Change will be assessed over the entire study, by comparing a pre-test the day before the intevention (which lasts 5 days) to a post-test the day after the intervention.	This is a standard psychophysical measure referenced in 100s of papers. Participants adjust a patch of color until it appears neither red nor green and this color is reported in standard colorimetric coordinates (e.g. CIE).

Trial Locations

Locations (1)

University of Minnesota; 🇺🇸 Minneapolis, Minnesota, United States