Imaging the Sigma1-receptor with SA4503 and positron emission tomography in depressive disorder
- Conditions
- (Major) Depressive Disorderdepression10027946
- Registration Number
- NL-OMON29746
- Lead Sponsor
- niversitair Medisch Centrum Groningen
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Pending
- Sex
- Not specified
- Target Recruitment
- 20
Fulfilling the criteria for major depression according to DSM-IV-TR criteria
Informed consent.
Regarded by the treating physician to have competence of judgement
Age 18-50 years
Current use of any medication (patients must be drug-free for three weeks) except use of benzodiazepines.
Drug or alcohol abuse in the past year
Prior cardiovascular disease, brain disease (including former traumatic contusion)
Evidence of any general medical disease, e.g. significant kidney or liver disease
Abnormalities at clinical neurological examination
Pregnancy ;(healthy controls): presence in the past of any psychiatric diagnosis, or the presence of a psychiatric disturbance in first-degree relatives of the subject, will be used as an exclusion criterion.
Study & Design
- Study Type
- Observational invasive
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <p>The main outcome variables will be the distribution volume, the binding<br /><br>potential and receptor density in the brain. Our hypothesis is that the number<br /><br>of sigma-receptors will be increased in persons with a depressive disorder.</p><br>
- Secondary Outcome Measures
Name Time Method <p>not applicable</p><br>