PET Study of Cerebral Metabolism of 11C-acetoacetate and 18F-FDG in Patients Under Moderate Ketosis
Trial Snapshot
- Phase
- Not Applicable
- Status
- Completed
- Sponsor
- Université de Sherbrooke
- Enrollment
- 10
- Primary Endpoint
- Mean in Cerebral Metabolic Rate of Glucose Before or After 4 Days of Ketogenic Diet
Study Overview
Brief Summary
Regional brain glucose hypometabolism occurs during aging and may contribute to the onset of aging-related cognitive impairment in humans. Ketones are the main alternative energy substrate to glucose for the brain. Several studies show that brain ketone uptake and metabolism are unaltered in cognitively-normal older persons and in Alzheimer's disease (AD). Nutritional ketosis is reported to have a positive impact on cognitive performances in mild cognitive impairment and AD. Nevertheless, changes in regional brain glucose and ketone uptake in adults are poorly understood during diet-induced experimental ketosis. The investigators hypothesis was that during diet-induced ketosis, brain ketone uptake would be directly correlated with the elevation of blood ketone levels and inversely correlated to brain glucose uptake.
Study Design
- Study Type
- Interventional
- Allocation
- Na
- Intervention Model
- Single Group
- Primary Purpose
- Basic Science
- Masking
- None
Eligibility Criteria
- Ages
- 18 Years to — (Adult, Older Adult)
- Sex
- All
- Accepts Healthy Volunteers
- Yes
Inclusion Criteria
- •Healthy adults
- •No signs of cognitive impairment
Exclusion Criteria
- •Not within the age limits
- •Pregnancy or breast feeding
- •Incapacity to withstand a supine position for 40 min
- •Non lacunar infarction
- •Known psychiatric history of schizophrenia, psychotic disorders, major affective disorders (bipolar disorder and major depression <5 years), panic disorder, obsessive compulsive disorders and other conditions that may affect memory
- •Epilepsy, brain trauma with loss of consciousness, subarachnoid hemorrhage
- •History of alcool and/or substances abuse (excessive alcool consumption ≥10 drinks/weeks)
- •Parkinson disease
- •Down syndrome
- •Inflammatory disease
- •Abnormal blood pressure, liver or kidney function, blood count
- •Dyslipidemia, hypothyroidism, osteoporosis
- •Presence of a metal object in the body
Arms & Interventions
Ketogenic diet
Pre/Post TEP study with a 4 days ketogenic diet (KD).
Interventions 1: Pre-KD = Participants did a TEP before starting the 4-day diet
Intervention 2: Post-KD = Participants did a TEP after completing the 4-day diet
Intervention: Pre-KD (Dietary Supplement)
Ketogenic diet
Pre/Post TEP study with a 4 days ketogenic diet (KD).
Interventions 1: Pre-KD = Participants did a TEP before starting the 4-day diet
Intervention 2: Post-KD = Participants did a TEP after completing the 4-day diet
Intervention: Post-KD (Dietary Supplement)
Outcomes
Primary Outcomes
Mean in Cerebral Metabolic Rate of Glucose Before or After 4 Days of Ketogenic Diet
Time Frame: At baseline (approximatively 1 month before the onset of the diet) and right after a 4 days ketogenic diet
Mean in Cerebral Metabolic Rate of Acetoacetate Before or After 4 Days of Ketogenic Diet
Time Frame: At baseline (approximatively 1 month before the onset of the diet) and right after a 4 days ketogenic diet
Secondary Outcomes
No secondary outcomes reported