PET Study of Cerebral Metabolism of 11C-acetoacetate and 18F-FDG in Patients Under Moderate Ketosis

Not Applicable

Completed

• Conditions: Healthy
• Interventions: Dietary Supplement: Pre-KD; Dietary Supplement: Post-KD

• Registration Number: NCT02409784
• Lead Sponsor: Université de Sherbrooke

Brief Summary

Regional brain glucose hypometabolism occurs during aging and may contribute to the onset of aging-related cognitive impairment in humans. Ketones are the main alternative energy substrate to glucose for the brain. Several studies show that brain ketone uptake and metabolism are unaltered in cognitively-normal older persons and in Alzheimer's disease (AD). Nutritional ketosis is reported to have a positive impact on cognitive performances in mild cognitive impairment and AD. Nevertheless, changes in regional brain glucose and ketone uptake in adults are poorly understood during diet-induced experimental ketosis. The investigators hypothesis was that during diet-induced ketosis, brain ketone uptake would be directly correlated with the elevation of blood ketone levels and inversely correlated to brain glucose uptake.

Detailed Description

Not available

Study Timeline

• Study Start: 2014-03
• Primary Completion: 2015-01
• Study Completion: 2015-01
• Study First Submitted: 2015-03-27
• Status Verified: 2015-04
• Study First Submitted QC: 2015-04-01
• Study First Posted: 2015-04-07
• Results First Submitted: 2017-08-29
• Results First Submitted QC: 2017-08-29
• Results First Posted: 2018-04-06
• Last Update Submitted: 2019-02-08
• Last Update Posted: 2019-02-15

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 10

Inclusion Criteria

• Healthy adults
• No signs of cognitive impairment

Exclusion Criteria

• Not within the age limits
• Pregnancy or breast feeding
• Incapacity to withstand a supine position for 40 min
• Non lacunar infarction
• Known psychiatric history of schizophrenia, psychotic disorders, major affective disorders (bipolar disorder and major depression <5 years), panic disorder, obsessive compulsive disorders and other conditions that may affect memory
• Epilepsy, brain trauma with loss of consciousness, subarachnoid hemorrhage
• History of alcool and/or substances abuse (excessive alcool consumption ≥10 drinks/weeks)
• Parkinson disease
• Down syndrome
• Inflammatory disease
• Abnormal blood pressure, liver or kidney function, blood count
• Dyslipidemia, hypothyroidism, osteoporosis
• Presence of a metal object in the body

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: SINGLE_GROUP

Arm && Interventions

Group	Intervention	Description
Ketogenic diet	Post-KD	Pre/Post TEP study with a 4 days ketogenic diet (KD). Interventions 1: Pre-KD = Participants did a TEP before starting the 4-day diet Intervention 2: Post-KD = Participants did a TEP after completing the 4-day diet
Ketogenic diet	Pre-KD	Pre/Post TEP study with a 4 days ketogenic diet (KD). Interventions 1: Pre-KD = Participants did a TEP before starting the 4-day diet Intervention 2: Post-KD = Participants did a TEP after completing the 4-day diet

Primary Outcome Measures

Name	Time	Method
Mean in Cerebral Metabolic Rate of Glucose Before or After 4 Days of Ketogenic Diet	At baseline (approximatively 1 month before the onset of the diet) and right after a 4 days ketogenic diet
Mean in Cerebral Metabolic Rate of Acetoacetate Before or After 4 Days of Ketogenic Diet	At baseline (approximatively 1 month before the onset of the diet) and right after a 4 days ketogenic diet