PET Study of Cerebral Metabolism of 11C-acetoacetate and 18F-FDG in Patients Under Moderate Ketosis
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 10
- 主要终点
- Mean in Cerebral Metabolic Rate of Glucose Before or After 4 Days of Ketogenic Diet
研究概览
简要总结
Regional brain glucose hypometabolism occurs during aging and may contribute to the onset of aging-related cognitive impairment in humans. Ketones are the main alternative energy substrate to glucose for the brain. Several studies show that brain ketone uptake and metabolism are unaltered in cognitively-normal older persons and in Alzheimer's disease (AD). Nutritional ketosis is reported to have a positive impact on cognitive performances in mild cognitive impairment and AD. Nevertheless, changes in regional brain glucose and ketone uptake in adults are poorly understood during diet-induced experimental ketosis. The investigators hypothesis was that during diet-induced ketosis, brain ketone uptake would be directly correlated with the elevation of blood ketone levels and inversely correlated to brain glucose uptake.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Basic Science
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Healthy adults
- •No signs of cognitive impairment
排除标准
- •Not within the age limits
- •Pregnancy or breast feeding
- •Incapacity to withstand a supine position for 40 min
- •Non lacunar infarction
- •Known psychiatric history of schizophrenia, psychotic disorders, major affective disorders (bipolar disorder and major depression <5 years), panic disorder, obsessive compulsive disorders and other conditions that may affect memory
- •Epilepsy, brain trauma with loss of consciousness, subarachnoid hemorrhage
- •History of alcool and/or substances abuse (excessive alcool consumption ≥10 drinks/weeks)
- •Parkinson disease
- •Down syndrome
- •Inflammatory disease
- •Abnormal blood pressure, liver or kidney function, blood count
- •Dyslipidemia, hypothyroidism, osteoporosis
- •Presence of a metal object in the body
研究组 & 干预措施
Ketogenic diet
Pre/Post TEP study with a 4 days ketogenic diet (KD).
Interventions 1: Pre-KD = Participants did a TEP before starting the 4-day diet
Intervention 2: Post-KD = Participants did a TEP after completing the 4-day diet
干预措施: Pre-KD (Dietary Supplement)
Ketogenic diet
Pre/Post TEP study with a 4 days ketogenic diet (KD).
Interventions 1: Pre-KD = Participants did a TEP before starting the 4-day diet
Intervention 2: Post-KD = Participants did a TEP after completing the 4-day diet
干预措施: Post-KD (Dietary Supplement)
结局指标
主要结局
Mean in Cerebral Metabolic Rate of Glucose Before or After 4 Days of Ketogenic Diet
时间窗: At baseline (approximatively 1 month before the onset of the diet) and right after a 4 days ketogenic diet
Mean in Cerebral Metabolic Rate of Acetoacetate Before or After 4 Days of Ketogenic Diet
时间窗: At baseline (approximatively 1 month before the onset of the diet) and right after a 4 days ketogenic diet
次要结局
未报告次要终点