Effect of Medical Interventions in Insulin Resistance on Prevalence of Abnormal Glucose Tolerance
- Registration Number
- NCT02502344
- Lead Sponsor
- Beijing Tsinghua Chang Gung Hospital
- Brief Summary
This research would take medical interventions in subjects of insulin resistance without abnormal glucose tolerance, to see if there were different prevalence of abnormal glucose tolerance in different groups.
- Detailed Description
The situation of type 2 DM prevention in China is serious. The commonly accepted natural course of type 2 DM is as follows: obesity, insulin resistance(hyperinsulemia), abnormal glucose tolerance, DM and complications of DM; correspondently, the function status of pancreas islet β cells are: normal, compensatory, decompensatory, impaired and failure. Post researches have proved that using medical interventions after the period of insulin resistance when the function status of β cells were compensatory, the course could not be reversed. There were few clinical researches about effects of medical interventions in the period of insulin resistance . This research would take medical interventions in subjects of insulin resistance without abnormal glucose tolerance, to see if there were different prevalence of abnormal glucose tolerance in different groups.
Recruitment & Eligibility
- Status
- UNKNOWN
- Sex
- All
- Target Recruitment
- 60
- BMI > 28kg/m2
- diagnosis of insulin resistance
- abnormal glucose tolerance
- function impairment of heart, liver or kidney
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description medical intervention group healthy lifestyle subjects in this group will accept healthy lifestyle changes such as food control and intensive exercise for 3 months first. Then their insulin resistance will be evaluated again . If their insulin resistance didn't improve, then they will take metformin 0.5g qd to reduce insulin resistance. If their insulin resistance improved, they will continued healthy lifestyle changes. medical intervention group Metformin subjects in this group will accept healthy lifestyle changes such as food control and intensive exercise for 3 months first. Then their insulin resistance will be evaluated again . If their insulin resistance didn't improve, then they will take metformin 0.5g qd to reduce insulin resistance. If their insulin resistance improved, they will continued healthy lifestyle changes.
- Primary Outcome Measures
Name Time Method prevalence of abnormal glucose intolerance two years after the subject joins the research OGTT test will be took in these subjects to find out if their glucose tolerance was abnormal
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
BEI JING Tsinghua Changguang Hospital
🇨🇳Beijing, Beijing, China