A pilot study on length of antibiotics for children hospitalized with pneumonia

Phase 4

Recruiting

• Conditions: Pneumonia in children; Respiratory - Other respiratory disorders / diseases; Infection - Studies of infection and infectious agents

• Registration Number: ACTRN12614000958684
• Lead Sponsor: Menzies School of Health Research

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2014-09-08
• Last Update Posted: 13 January 2020

Recruitment & Eligibility

• Status: Recruiting
• Sex: All
• Target Recruitment: 20

Inclusion Criteria

(a) Hospitalised children who have been unwell for <7-days with pneumonia
(b) Alveolar consolidation on CXR; and
(c) After 48-72 hours of IV penicillin/ampicillin the children are afebrile, with improved respiratory symptoms and signs, SpO2 >92% in air and are ready to be switched to oral antibiotics

Exclusion Criteria

Presence of one or more:
(a) underlying chronic illness (not asthma): chronic lung disease of infancy, bronchiectasis, cystic fibrosis, congenital heart disease, or immunodeficiency
(b) complicated pneumonia (effusion, empyema, abscess); non-alveolar pneumonia; those requiring assisted ventilation or circulatory support; or where a treatment course of IV antibiotics other than penicillin/ampicillin has been used (eg. anti-staphylococcal antibiotics, cephalosporins or macrolides);
(c) extra-pulmonary infection requiring antibiotic therapy (eg. meningitis); or
(d) beta-lactam antibiotic allergy

Study & Design

• Study Type: Interventional
• Study Design: Not specified