Managing Bacterial Pneumonia in Children Without Antimicrobials
- Conditions
- Pneumonia
- Registration Number
- NCT03256474
- Lead Sponsor
- ARCIM Institute Academic Research in Complementary and Integrative Medicine
- Brief Summary
Retrospective cohort analysis of children hospitalized for pneumonia comparing disease severity on admission, clinical course, treatment and outcomes and prospective telephone based Follow-Up assessement.
- Detailed Description
The investigators will conduct a retrospective cohort analysis of children hospitalized for pneumonia at the Filderklinik between December 2006 and November 2010. The Bacterial Pneumonia Score, a validated composite laboratory, clinical and radiologic score developed by Moreno et al, will be retrospectively applied to define cases as either viral or bacterial pneumonia. The investigators will compare disease severity on admission, clinical course, and outcomes (in terms of complications, length of stay and readmission rates) between antimicrobial and non-antimicrobial managed bacterial pneumonia cases. Long-term Follow-Up will be assessed by telephone interviews with the parents.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 350
- Hospital admission at the pediatric department of the Filderklinik.
- Admission diagnosis pneumonia (ICD J12.0, J12.1, J12.8, J12.9, J14, J15.1, J15.6, J15.7, J15.8, J15.9, J16.8, J18.0, J18.1, J18.8, J18.9 - all 12s, 15s, 16s, 18s)
- None
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Readmission rate 7 - 10 years after hospitalization Readmission rate for pneumonia among children with bacterial pneumonia, managed with or without antimicrobials
Days of supplemental oxygen need Between admission and 3 months after discharge Days of supplemental oxygen need in children with bacterial pneumonia, managed with or without antimicrobials
Medical complication rate Between admission and 3 months after discharge Medical complication rate among children with bacterial pneumonia, treated with or without antimicrobials
Temperature normalization Between admission and 3 months after discharge Days to temperature normalization (\< 38°C) in children with bacterial pneumonia, managed with or without antimicrobials
Cure rate of non-antimicrobial management of bacterial pneumonia Between admission and 3 months after discharge Cure rate of non-antimicrobial management of bacterial pneumonia (in the following and in the final publication, the term "bacterial pneumonia" will be used for children who fulfill the Moreno criteria for pneumonia): % of children managed without antimicrobials since admission, without subsequent need for antimicrobials or readmission.
Length of hospital stay Between admission and 3 months after discharge Length of hospital stay for children with bacterial pneumonia, managed with or without antimicrobials
- Secondary Outcome Measures
Name Time Method Changes in oxygen saturation Between admission and 3 months after discharge Changes in oxygen saturation as an indicator for pulmonary infection
Rate of chronic and acute-infectious co-morbidities Day of admission Rate of chronic and acute-infectious co-morbidities on admission in children with bacterial pneumonia, subsequently managed with or without antimicrobials
Number of patients treated with antipyretics Between admission and 3 months after discharge Number of patients treated with antipyretics
Changes in respiratory rate Between admission and 3 months after discharge Changes in respiratory rate as an indicator for pulmonary infection
Changes in pH Between admission and 3 months after discharge Changes in pH as an indicator for respiratory distress
Changes in Bacterial Pneumonia Score Between admission and 3 months after discharge Changes in Bacterial Pneumonia Score as an indicator for pulmonary infection
Utilization rate of a package of complementary treatment measures Between admission and 3 months after discharge Utilization rate of a package of complementary treatment measures from anthroposophic medicine (including oral medications, inhalation and external nursing applications) in children managed with or without antimicrobials
Changes in CRP Between admission and 3 months after discharge Changes in CRP as an indicator for infection
Changes in leukocyte count Between admission and 3 months after discharge Changes in leukocyte count as an indicator for infection
Changes in pCO2 Between admission and 3 months after discharge Changes in pCO2 as an indicator for respiratory distress
Antimicrobial treatment rate in children with viral pneumonia Between admission and 3 months after discharge Antimicrobial treatment rate in children classified as viral pneumonia by Bacterial Pneumonia Score
Trial Locations
- Locations (1)
Arcim Institute
🇩🇪Filderstadt, Baden-Württemberg, Germany