Blood Outgrowth Endothelial Cells (BOECs) to study endothelial metabolic pathophysiology in diabetes patients.

Completed

• Conditions: 10029149; diabetes; diabetes mellitus; 10012653

• Registration Number: NL-OMON46605
• Lead Sponsor: eids Universitair Medisch Centrum

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 15 April 2024

Recruitment & Eligibility

• Status: Completed
• Sex: Not specified
• Target Recruitment: 100

Inclusion Criteria

In order to be eligible to participate in this study, the following criteria must be met:
- Age 18 years or older.
- Prior diagnosis of type 2 diabetes mellitus.
- Subject is willing to participate in the study, must be able to give informed consent and the consent must be obtained prior to any study procedure.;Healthy Controls
- Age 18 years or older, participants will be age-matched with recruited patients.
- Not known with type 2 diabetes mellitus

Exclusion Criteria

A potential subject who meets any of the following criteria will be excluded from participation in this study:
- Any concurrent illness, disability or clinically significant abnormality that may, as judged by the investigator, affect interpretation.
- Non-diabetic renal disease e.g. known polycystic kidney disease.
- Prominent renal deterioration (CKD-EPI *60 ml/min/1.73m² )
- Use of LMW heparin and/or immunosuppressive drugs.
- Signs of active infection or autoimmune disease, requiring systemic treatment.
- A psychiatric, addictive or any disorder that compromises ability to give truly informed consent for participation in this study.
- Use of any investigational drug.

Study & Design

• Study Type: Observational invasive
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>Cell metabolism, endothelial maturation markers and angiogenic markers.</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>nvt</p><br>