Randomized, controlled study of the effect of local and systemic factors on the postoperative course of patients with chronic rhinosinusitis (CRS) who underwent functional endoscopic sinus surgery (FESS).

Aristotle Univeristy of Thessaloniki0 个研究点目标入组 88 人开始时间: 2021年6月7日最近更新: 2024年7月29日

适应症

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•Patients were at least 18 years old, diagnosed with CRS with or without nasal polyposis (EPOS) and scheduled for bilateral functional endonasal endoscopic sinus surgery (FESS) or bilateral revision FESS. Patients with cystic fibrosis, immunodeficiencies, mucociliary dysfunction, fungal balls, systemic vasculitis, granulomatous diseases or cocaine abuse were excluded. The indication for surgery was made when medical treatment as recommended by the EPOS treatment algorithms failed, including saline irrigations, nasal corticosteroids, and one or more courses with oral treatment with oral corticosteroids and/or antibiotics. Nasal corticosteroids were stopped one week before surgery. Systemic corticosteroid drugs were stopped for at least one month before surgery.

•The following are defined as exclusion criteria for patients:
•Immunotherapy, decongestants (oral or nasal), cromolyns, ipatropium bromide, montelukast and monoclonal antibodies were prohibited before and during the study.
•history of recent upper respiratory infection or exacerbation of chronic rhinosinusitis up to 3 weeks before surgery.
•Chronic steroid intake for any reason other than chronic rhinosinusitis.
•Medical history of head and neck cancer and radiotherapy in the head area.
•Medical history of substance abuse or alcohol.
•Hypersensitivity to doxycycline.
•Taking other medications that could affect doxycycline intake.
•Patients with known severe liver, kidney, skin or GI disease.

发起方

Aristotle Univeristy of Thessaloniki