NCT07164196已完成不适用
Evaluation of Angiopoietin-like Protein 4 Levels in Patients With Endometriosis
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 80
- 试验地点
- 1
- 主要终点
- Serum and peritoneal fluid Angiopoietin-like protein-4 level
研究概览
简要总结
Endometriosis is a chronic inflammatory disease associated with pelvic pain, dyspareunia, and impaired ovarian reserve. Cancer antigen-125 (CA-125) is widely studied but limited by low specificity, while angiopoietin-like protein-4 (ANGPTL4) has emerged as a potential biomarker due to its role in angiogenesis and inflammation. In the current study it was aimed to investigate serum and peritoneal fluid ANGPTL4 levels in women with endometriosis compared to healthy controls, and to evaluate their associations with clinical symptoms, serum CA-125, and anti-Müllerian hormone levels.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 44 Years（Adult）
- 性别
- Female
- 接受健康志愿者
- 是
入选标准
- •Diagnosis of endometriosis for study group who underwent laparoscopic endometriosis surgery
- •Healthy women for control group
排除标准
- •Cardiovascular diseases including hypertension
- •Type 1 or type 2 diabetes mellitus
- •Morbid obesity
- •Primary adrenal insufficiency
- •Uterine fibroids
- •Thyroid dysfunctions including Hashimoto thyroiditis and Grave's disease
- •Hepatic dysfunctions
- •Renal insufficiency
- •Genetic disorders in chromosome constitution or karyotype analysis including monosomy X, trisomy X and gene mutations as BMP15, FMR I, POFIB, and GDF9
- •Neurologic diseases
- •Psychiatric disorders
- •Autoimmune diseases or syndromes including Addison's disease, autoimmune syndromes, scleroderma, Sjogren's syndrome, myasthenia gravis, inflammatory bowel diseases, multiple sclerosis, rheumatoid arthritis, systemic lupus erythematosus and familial Mediterranean fever
- •History of any malignancy
- •History of exposure to chemotherapeutic agents or radiotherapy
结局指标
主要结局
Serum and peritoneal fluid Angiopoietin-like protein-4 level
时间窗: day 1
Nanogram/milliliter
次要结局
- Serum cancer antigen 125 level(day 1)
研究者
Merve Didem Eşkin Tanrıverdi
Medical Doctor
Ankara City Hospital Bilkent
研究点 (1)
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