A Phase I, Randomized, Observer-blind, Single-center, Vehicle- And Comparator-controlled, Initial Dose-ranging Study To Assess The Antipsoriatic Efficacy Of Different Concentrations Of An2728 Cream In A Psoriasis Plaque Test
试验速览
- 阶段
- 1 期
- 状态
- 已完成
- 发起方
- Pfizer
- 入组人数
- 12
- 试验地点
- 1
- 主要终点
- Efficacy of the active study preparations compared to the corresponding vehicle using differences in infiltrate thickness on study day 12.
研究概览
简要总结
The purpose of this study is to investigate dose-response relationship, antipsoriatic efficacy and safety of different concentrations of topical formulations with AN2728 in subjects with psoriasis vulgaris.
详细描述
The study will be performed in 12 male subjects with stable psoriatic plaques. The study preparations and the comparator will be tested observer-blind. Treatments will be randomly assigned to the test fields. All subjects will receive all treatments, with intraindividual comparison of the treatments.
Altogether six test fields will be examined per subject (four active AN2728 creams of different concentrations: 2 %, 1 %, 0.3 %, 0.03 %, the active ingredient-free vehicle, and a marketed corticoid preparation). The test fields will be treated occlusively over a study period of 12 days. Topical application of approximately 200 uL of each assigned intervention is administered per treatment, for a total of 10 treatments over a 12-day treatment period.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 主要目的
- Treatment
- 盲法
- Double (Participant, Outcomes Assessor)
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- Male
- 接受健康志愿者
- 否
入选标准
- •male subjects aged 18 years or older
- •subjects with psoriasis vulgaris in a chronic stable phase and stable plaques with an area sufficient for five treatment fields
- •the physical examination must be without disease findings unless the investigator considers an abnormality to be irrelevant to the outcome of the study
- •written informed consent obtained
排除标准
- •subjects with psoriasis guttata or pustular psoriasis
- •subjects who require systemically acting medications for the treatment of psoriasis, which might counter or influence the study objectives, e.g. corticosteroids, cytostatics
- •local treatment with antipsoriatics (like vitamin D, dithranol, glucocorticosteroids; except for salicyclic acid in vaseline) in the 4 weeks preceding and during the study; and any antipsoriatic treatment on the plaques (including corticosteroids, except for salicyclic acid) in the 8 weeks preceding and during the study.
- •systemic treatment with antipsoriatics in the three months preceding and during the study
- •treatment with systemic or locally acting medications which might counter or influence the study aim (e.g. MAO inhibitors, anti-epileptic drugs, anti-psychotic drugs) or medications which are known to provoke or aggravate psoriasis, e.g. Beta-blocker, antimalarial drugs and lithium drugs within two weeks before the beginning of the study and during the study.
- •known allergic reactions to the active ingredients or other components of the study preparations or comparators
- •blood pressure and heart rate outside the following allowed ranges: systolic blood pressure 80-160 mm Hg, diastolic blood pressure 60 - 100 mm Hg, heart rate 40-120 beats/min
- •evidence of drug abuse
- •UV-therapy within 4 weeks before beginning and during the study
- •Symptoms of a clinically significant illness that may influenced the outcome of the study in the 4 weeks before and during the study
- •participation in another clinical trial involving pharmaceutical products in the 4 weeks preceding and during the study
- •in the opinion of the investigator or physician performing the initial examination the patient should not participate in the study, e.g. due to probable noncompliance or inability to understand the study and give adequately informed consent
- •subject is institutionalized because of legal or regulatory order
研究组 & 干预措施
1
AN2728 Cream, 2%
干预措施: AN2728 Cream, 2% (Drug)
2
AN2728 Cream, 1%
干预措施: AN2728 Cream, 1% (Drug)
3
AN2728 Cream, 0.3%
干预措施: AN2728 Cream, 0.3% (Drug)
4
AN2728 Cream Vehicle
干预措施: AN2728 Cream Vehicle (Drug)
5
Betnesol®-V Creme (betamethasone 0.1 %)
干预措施: Betnesol®-V Creme, 0.1% (Drug)
结局指标
主要结局
Efficacy of the active study preparations compared to the corresponding vehicle using differences in infiltrate thickness on study day 12.
时间窗: Day 12
次要结局
- Change in infiltrate thickness(Day 8)
- Sonographic measurements of infiltrate thickness(Day 8, Day 12)
- Clinical assessment scores for assessment of efficacy(Day 8, Day 12)
- The AUC of the infiltrate thickness(Day 8, Day 12)