Comparative evaluation of Intravenous Ketamine and Magnesium Sulphate for Attenuation of post operative pain and stress response in lower abdominal surgery

Introduction: Pain is a common phenomenon in postoperative period. Adequate post operative pain management after major surgeries is important for earlier mobilization, to reduce length of hospital stay and for prevention of chronic pain syndrome.

Aims and Objectives : We aim to evaluate and compare the effect of intravenous ketamine and magnesium sulphate on post operative analgesic consumption after lower abdominal surgery as primary outcome and stress response as secondary outcome.

Material and Methods: The study will be conducted in comparative manner in GGS Medical College and Hospital, Faridkot on 60 patients belonging to American Society of Anaesthesiologists (ASA) Grade I / II; aged 18-65 years; scheduled for lower abdominal surgery under general anaesthesia . Patients will be allocated into three groups of 30 each. • Group K - These patients will receive intravenous ketamine: bolus of 0.2mg/kg after induction of anaesthesia followed by infusion of 0.05mg/kg/h till end of surgery. • Group M - These patients will receive intravenous magnesium sulphate: bolus of 50 mg/kg after induction of anaesthesia followed by 10mg/kg/h till end of surgery. Intraoperative opioid consumption, total analgesic consumption in 24 hour post operatively, pain score, CRP levels preoperative and postoperative, emergence time and any side effects of the drugs will be assessed. The data will then be statistically analysed.