Early Versus Late Use of Hi-VNI in Covid-19

Completed

• Conditions: COVID-19

• Registration Number: NCT05663138
• Lead Sponsor: Assiut University

Brief Summary

This study evaluate early administration of high-velocity nasal insufflation in COVID-19 patients presented with acute respiratory failure after failure of conventional low flow nasal cannula bypassing the escalating step of Non re-breathing mask where early use of High velocity nasal insufflations achieved better improvement of respiratory distress, lower oxygen requirements and shorter ICU stay.

Detailed Description

The study included 30 COVID-19 patients admitted to intensive care of COVID-19 zone, chest Department, quarantine section, Assiut University hospital. All patients were positive for COVID-19 infection by nasopharyngeal swab for detection of viral RNA by real time PCR for SAR-COV-2 RNA assay on 7500 Applied Bio-system. All patients received treatment based on the protocol of Egyptian Ministry of Health, Patients enrolled in the study were categorized into 2 groups, the 1st group included patients whom were shifted to Hi-VNI after failure of high flow nasal cannula, while the 2nd group included patients shifted to Hi-VNI after failure of non-rebreathing mask, using a Precision flow vapotherm (vapotherm, Inc, 100 Domain device Exeter, NH 03833, T: 603-658-0011, USA), that provide high velocity humidified flow through narrow bore nasl prongs

Study Timeline

• Study Start: 2021-10-01
• Primary Completion: 2022-02-28
• Study Completion: 2022-03-15
• Status Verified: 2022-12
• Study First Submitted: 2022-12-20
• Study First Submitted QC: 2022-12-22
• Last Update Submitted: 2022-12-22
• Study First Posted: 2022-12-23
• Last Update Posted: 2022-12-23

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 30

Inclusion Criteria

• 1-severe COVID Patients with hypoxemic respiratory failure. 2- Patients with no comorbidities

Exclusion Criteria

1. Non severe COVID Patients
2. Patients with comorbidities (e.g chronic chest dis, DM, renal failure and hepatic failure
3. Patients indicated for mechanical ventilation
4. Patients with marked hypercapnia in need for non-invasive ventilation

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Improved oxygenation	through the study completion, average 6 months	Patients with early use of Hi-VNI had better improvement of oxygenation than those with late use of Hi-VNI

Trial Locations

Locations (1)

Assiut University; 🇪🇬 Assiut, Egypt