Investigating the Inotropic Potential of Apelin
- Registration Number
- NCT01179061
- Lead Sponsor
- University of Edinburgh
- Brief Summary
The apelin-APJ system is a recently discover hormone system that has several important actions in the cardiovascular system. Apelin causes the heart pump with more force and also causes blood vessels to relax. Studies to date show that people with reduced pumping function of the heart have lower levels of apelin in the bloodstream compared to people with normal heart function. We have previously given apelin to healthy volunteers and people with reduced pumping function and this increases the heart's contraction. However, this has only been assessed over a short time period, around fifteen minutes, and we now want to know if this effect is seen over a longer period.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 24
Healthy volunteers:
>18yrs
Heart failure patients;
- New York Heart Failure class II-IV
- Ejection fractional <35% or fractional shortening <20% within previous 6months.
All subjects,
- Females of child bearing age not on adequate contraception
- Lack of informed consent
- Age <18yrs
- Current involvement in any other research study
- Systolic BP >190 or <100
- Malignant arrhythmias
- Renal or hepatic failure
- Haemodynamically significant aortic stenosis
- Severe or significant co-morbidity
- Pacemakers
Healthy volunteers
- Any regular medication
- Previous history of any cardiovascular disease
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- CROSSOVER
- Arm && Interventions
Group Intervention Description Apelin infusion Apelin 6 hour infusion of apelin peptide into circulation Placebo Placebo Infusion of saline into systemic circulation
- Primary Outcome Measures
Name Time Method cardiac output 6 hours We will assess, using thoracic bioimpedance cardiography, the change in cardiac output in response to apelin infusion
- Secondary Outcome Measures
Name Time Method Urine volume 6 hours All urine will be collected during the studya and we will assess volume and relevant biochemical/humoral factors
Pulmonary artery pressure 1 hour Using echocardiography we will estimate the pulmaonary artery pressure from pulmonary velocity and assess any change during the first hour of study.
Trial Locations
- Locations (3)
Clincial Research Facility, Royal Infirmary of Edinburgh, 51 Little France Cresc
🇬🇧Edinburgh, United Kingdom
Gareth Barnes
🇬🇧Edinburgh, United Kingdom
University of Edinburgh
🇬🇧Edinburgh, United Kingdom