The role of CircRNA-miRNA-mRNA regulatory network in the occurrence and development of periodontitis with diabetes mellitus

Phase 1

• Conditions: diabetic periodontitis

• Registration Number: ChiCTR2200056295
• Lead Sponsor: West China Hospital of Stomatology, Sichuan University

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 2 September 2024

Recruitment & Eligibility

• Status: Pending
• Sex: All
• Target Recruitment: Not specified

Inclusion Criteria

Health group:<br>1. Periodontal health;<br>2.The number of remaining teeth in the mouth is not less than 20;<br>3. Good health, no history of smoking, no history of diabetes or family history, normal blood sugar level;<br>4. No infections in digestive, respiratory, reproductive, urinary systems or other parts of the body, and no other serious diseases.<br>Periodontitis group:<br>1. >= 30% of the tooth position in the mouth spreads;<br>2.The most serious loss of adhesion between neighbors >= 5mm;<br>3. Bone resorption to 1/2 of the root or 1/3 of the root tip;<br>4. Remaining teeth may be less than 20, which may be accompanied by other complicated symptoms: root bifurcation disease, secondary complication trauma, occlusal disorder, etc.;<br>5. The degree of periodontal damage matches the degree of plaque adhesion;<br>6. No history of periodontal disease treatment within six months (otherwise it will affect the real situation).<br>Diabetic periodontitis group:<br>1. The patient was diagnosed with type 2 diabetes with a course of 1 year or more; there was no history of other serious systemic diseases and complications; after detailed physical examination, no history of inflammation, infection and disease in the respiratory, digestive, genitourinary and other parts of the body and other parts of the body;<br>2. The patient's diabetic condition, and the dosage of medication has not changed significantly recently;<br>3. No smoking history;<br>4. The inclusion criteria for periodontitis are the same as above.

Exclusion Criteria

Excluded cases: hematopathy, liver damage, kidney disease, tumor, acute macrovascular complications within 1 month, taking any drugs that affect systemic inflammation indicators in the past 3 months, history of major surgical trauma within half a year, within half a year Have undergone periodontal treatment.

Study & Design

• Study Type: Observational study
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Circrna content in gingival tissue;