CTIS2024-511711-21-00
Active, Not Recruiting
Phase 1
ChemoRadiotherapy with Or Without surgery followed by consolidation Durvalumab (CROWD): a phase IV feasibility trial
Overview
- Phase
- Phase 1
- Intervention
- Not specified
- Conditions
- Stage III non-small cell lung cancer
- Sponsor
- Amsterdam UMC Stichting
- Enrollment
- 38
- Status
- Active, Not Recruiting
- Last Updated
- last year
Overview
Brief Summary
No summary available.
Investigators
Eligibility Criteria
Inclusion Criteria
- •Histologically or cytologically confirmed stage III (non\-N3\) NSCLC (TNM 8th edition), before start of chemoradiotherapy, In case of suspected N2\-disease, mediastinal invasive staging (EUS, EBUS and/or mediastinoscopy) to prove N2 involvement before start of concurrent CRT is mandatory., Initial MDT recommendation for a non\-surgical treatment comprising CRT followed by durvalumab
Exclusion Criteria
- •Patients with TxN3 or M1 disease, The use of any CRT schemes other than those in ESMO recommendations (platinum doublet, 30 once\-daily fractions of 2 Gy), Patients deemed inoperable based on cardiopulmonary function tests or comorbidity
Outcomes
Primary Outcomes
Not specified
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