The effect of herbal supplements on neurotransmitters in the formation of dementia
Phase 2
- Conditions
- Dementia.Dementia in other diseases classified elsewhere without behavioral disturbanceF03. 90
- Registration Number
- IRCT20211012052739N1
- Lead Sponsor
- Fasa University of Medical Sciences
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete
- Sex
- All
- Target Recruitment
- 105
Inclusion Criteria
Inclusion age (at least 65 years)
Complete DSM_IV diagnostic questionnaires by a partner specialist
Proof of dementia by CT scan, MRI
The same conditions as the severity of the disease
Exclusion Criteria
Having similar neurological disorders
Alcohol consumption history in the past year
History of gastrointestinal diseases
Study & Design
- Study Type
- interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method GABA amino butyric acid. Timepoint: At the beginning of the study (before the intervention) and 60 days after starting the drug. Method of measurement: High-performance liquid chromatography.;Dopamine. Timepoint: At the beginning of the study (before the intervention) and 60 days after starting the drug. Method of measurement: High-performance liquid chromatography.;Serotonin. Timepoint: At the beginning of the study (before the intervention) and 60 days after starting the drug. Method of measurement: High-performance liquid chromatography.;Glutamate. Timepoint: At the beginning of the study (before the intervention) and 60 days after starting the drug. Method of measurement: High-performance liquid chromatography.
- Secondary Outcome Measures
Name Time Method Improving patient memory and slowing the progression of patient perceptual defects. Timepoint: 60 days after starting Berberine supplementation. Method of measurement: Questionnaire for scores of clinical change assessment (CGI) and psychiatric grading criteria (BpRS).