on invasive imaging of human cartilage by scintigraphy using novel radiolabelled chondroitin sulfate to prove cartilage degeneration in comparision with proteoglycan specific Magnetic Resonance Imaging.

Phase 1

Conditions: Examination of the fundamental usefulness of 99mTcCS for scintigraphy.

Registration Number: EUCTR2009-016920-30-AT

Lead Sponsor: Medizinische Universitaet Wien, Universitaetsklinik fÃ¼r Radiologie und Nuklearmedizin

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: ot Recruiting

Sex: All

Target Recruitment: 10

Inclusion Criteria

- Age between 18 and 90 years
- Early arthritis secured by MRI
Are the trial subjects under 18? no
Number of subjects for this age range:
F.1.2 Adults (18-64 years) yes
F.1.2.1 Number of subjects for this age range
F.1.3 Elderly (>=65 years) yes
F.1.3.1 Number of subjects for this age range

Exclusion Criteria

- Pregnancy
- Age <18

Study & Design

Study Type: Interventional clinical trial of medicinal product

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Main Objective: Diagnostic position and/or diagnostic protection in the comparison with MRI of findings;Secondary Objective: -Quantification of degeneration by means of tracer Uptake regulation <br>-Quantification of therapy success after surgical cartilage repair (transplant).;Primary end point(s): -Early recognition of the arthritis in degenerated cartilage (in particular intra<br>articular). <br>-Evaluation of the target-specific enrichment of both tracers in degenerated versus native, hyalinen cartilage fabrics <br>-quantification of the pathological changes by means of determination of the tracer uptakes cartilage fabric<br>-Follow UP investigations concerning treatment success with cartilage transplants after surgical cartilage repair

Secondary Outcome Measures