An fMRI investigation of the neural substrate of cognitive insight in non-clinical subjects

Completed

• Conditions: zelf-reflectie en open staan voor mening van anderen; it involves healthy subjects.; This study is not aimed at a certain disorder

• Registration Number: NL-OMON43071
• Lead Sponsor: eurowetenschappen

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Last Update Posted: 28 February 2024

Recruitment & Eligibility

• Status: Completed
• Sex: Not specified
• Target Recruitment: 200

Inclusion Criteria

* Being right-handed (based on Edinburgh Handedness inventory questionnaire)
* Age 18-65
* Normal (or corrected to normal) vision
* fMRI-compatible
* Capable of giving informed consent
* Fluent in written and spoken Dutch

Exclusion Criteria

* Not matching any of the inclusion criteria
* Matching any criterion in the fMRI exclusion list, including, but not limited to, claustrophobia, infarctions, epilepsy or family history of epilepsy, presence of metal inside the body, presence of electric/electronic devices inside the body (pacemakers, etc.), presence of intracardial lines, (suspicion of) pregnancy, tattoo(s) that contain red pigment, any risk of having metal particles in the eyes
* Non-removable dentures
* Use of medication that can influence task performance. For example, medication that target blood pressure or heart rate (e.g. beta-blockers). Also, use of antidepressants, anxiolytic, and anti-epileptic drugs
* Use of drugs such as cannabis, XTC or other recreational drugs
* Presence or history of neurological, psychiatric or substance dependence disorder
* Previous mindfulness or other formal meditation experience

Study & Design

• Study Type: Observational non invasive
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>The main study parameters are brain activation and/or connectivity during<br /><br>tasks, and brain (functional and structural) connectivity during resting state,<br /><br>in relation to cognitive insight. Blood-oxygen-level-dependent (BOLD) signal<br /><br>will be measured during the performance of two different tasks and at rest<br /><br>using fMRI. In addition, a special kind of diffusion-weighted imaging (DWI)<br /><br>called diffusion tensor imaging (DTI) will be used to examine the relationship<br /><br>between the integrity of white matter tracts and cognitive insight, while<br /><br>structural MRI scans will be used to examine grey matter volume in relationship<br /><br>to cognitive insight. </p><br>

Secondary Outcome Measures

Name	Time	Method
<p>Secondary study parameters are cognitive test scores on the Sustained Attention<br /><br>to Response Task (sustained attention, inhibition and meta-awareness).</p><br>